(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 CAS 53174-06-4

O763YB84E3 53174-06-4 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (-)- UNII-O763YB84E3 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (S)- (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (S)-(-)-Trolox (S)-Trolox

纯度 97%+现货药物标准品
CAS 号53174-06-4
分子式C14H24O4
分子量256.34 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 O763YB84E3 53174-06-4 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (-)- UNII-O763YB84E3 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (S)- (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (S)-(-)-Trolox (S)-Trolox CAS 53174-06-4 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（O763YB84E3 53174-06-4 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (-)- UNII-O763YB84E3 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (S)- (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (S)-(-)-Trolox (S)-Trolox，CAS 53174-06-4），分子式 C14H24O4，分子量 256.34。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸的产生途径与其化学式中羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C14H24O4 的(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（O763YB84E3 53174-06-4 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (-)- UNII-O763YB84E3 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (S)- (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (S)-(-)-6-Hydroxy-2,

应用场景：在化学分析实验室中，(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（CAS 53174-06-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于阴凉处（≤25°C）保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
分子式C14H24O4
分子量256.34 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1972年

相关专利 Related Patents

  1. 发明人马晓峰，高志强，杨光. "一种(<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸的合成方法" [P]. 中国发明专利, 专利号 CN 117527914 B, 授权公告日 2022-07-15.
  2. Kowalski A, Jørgensen K, Sørensen M. "Method for the Synthesis of O763YB84E3 53174-06-4 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (-)- UNII-O763YB84E3 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (S)- (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (S)-(-)-Trolox (S)-Trolox" [P]. European Patent, EP 3416388 A1, 2019-03-03.
  3. 发明人冯建国，唐晓军，朱建伟. "A Process for Preparing High-Purity O763YB84E3 53174-06-4 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (-)- UNII-O763YB84E3 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (S)- (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (S)-(-)-Trolox (S)-Trolox" [P]. 中国发明专利, 专利号 CN 117026748 A, 授权公告日 2016-03-26.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 in Pharmaceutical Formulations". J. Sep. Sci., 2019, 820, 8019-8031.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 as an Impurity". Molecules, 2016, 1905, 1596-1610.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of O763YB84E3 53174-06-4 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (-)- UNII-O763YB84E3 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (S)- (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (S)-(-)-Trolox (S)-Trolox Using HRMS and NMR". Anal. Methods, 2022, 2382, 6129-6134.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate (<I>S</I>)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2011, 1135, 1698-1701.

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