香豆素 153 CAS 53518-18-6

2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H-[1]benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzo[de]anthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one Coumarin 153 Coumarin 540A

纯度 97%+现货药物标准品
CAS 号53518-18-6
分子式C16H20F3NO2
分子量315.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

香豆素 153 2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H-[1]benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzo[de]anthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one Coumarin 153 Coumarin 540A CAS 53518-18-6 结构式 Chemical Structure

产品介绍 Description

香豆素 153（2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H-[1]benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzo[de]anthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one Coumarin 153 Coumarin 540A）是药物分析与质量控制领域常用的药物标准品，CAS 号 53518-18-6。分子式 C16H20F3NO2，分子量 315.33。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

香豆素 153的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 53518-18-6 对应的化合物香豆素 153（英文标识 2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H-1benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzodeanthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H-pyrano2,3-fpyrido3,2,1-ijquinolin-11(5H)-one Coumarin 153 Coumarin 540A），化学式 C16H20F3NO2，相对分子质

应用场景：针对化学分析用途，香豆素 153（2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H- 1 benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzo de anthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydr

理化性质 Physical & Chemical Properties

中文名称香豆素 153
分子式C16H20F3NO2
分子量315.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1972年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. 发明人郭海燕，钱学锋，周伟. "一种香豆素 153的合成方法" [P]. 中国发明专利, 专利号 CN 116110299 B, 授权公告日 2023-01-17.
  2. 发明人朱建伟，周伟，王建平. "Method for the Synthesis of 2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H-[1]benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzo[de]anthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one Coumarin 153 Coumarin 540A" [P]. 中国发明专利, 专利号 CN 115644323 B, 授权公告日 2018-04-04.
  3. 发明人高志强，马晓峰，钱学锋. "A Process for Preparing High-Purity 2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H-[1]benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzo[de]anthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one Coumarin 153 Coumarin 540A" [P]. 中国发明专利, 专利号 CN 112880158 B, 授权公告日 2025-07-19.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 香豆素 153 in Pharmaceutical Formulations". Food Chem., 2010, 873, (6), 383-390.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 香豆素 153 as an Impurity". Anal. Methods, 2020, 1054, (12), 707-714.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 2,3,6,7-Tetrahydro-9-(trifluoromethyl)-1H,5H,11H-[1]benzopyrano(6,7,8-ij)quinolizin-11-one 2,3,6,7-Tetrahydro-9-trifluoromethyl-1H,5H-quinolizino(9,1-gh)coumarin 53518-18-6 8-Trifluoromethyl-2,3,5,6-4H-1,H-11-oxa-3a-aza-benzo[de]anthracen-10-one 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one Coumarin 153 Coumarin 540A Using HRMS and NMR". J. Pharm. Biomed. Anal., 2015, 312, (10), 4708-4733.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 香豆素 153 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2015, 221, (9), 8035-8038.

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