2-Chloro-3-methyl-4-[(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo[1,2-<I>c</I>]imidazol-2(3<I>H</I>)-yl]benzonitrile CAS 627530-84-1

627530-84-1 9BLW27W4X7 BMS-564929 BMS 564929 (7R,7aS)-2-(3-Chloro-4-cyano-2-methylphenyl)-7-hydroxytetrahydro-2H-pyrrolo(1,2-e)imidazole-1,3-dione UNII-9BLW27W4X7 BMS-564,929

纯度 97%+现货药物标准品
CAS 号627530-84-1
分子式C14H12ClN3O3
分子量305.72 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-Chloro-3-methyl-4-[(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo[1,2-<I>c</I>]imidazol-2(3<I>H</I>)-yl]benzonitrile 627530-84-1 9BLW27W4X7 BMS-564929 BMS 564929 (7R,7aS)-2-(3-Chloro-4-cyano-2-methylphenyl)-7-hydroxytetrahydro-2H-pyrrolo(1,2-e)imidazole-1,3-dione UNII-9BLW27W4X7 BMS-564,929 CAS 627530-84-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品2-Chloro-3-methyl-4-[(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo[1,2-<I>c</I>]imidazol-2(3<I>H</I>)-yl]benzonitrile（627530-84-1 9BLW27W4X7 BMS-564929 BMS 564929 (7R,7aS)-2-(3-Chloro-4-cyano-2-methylphenyl)-7-hydroxytetrahydro-2H-pyrrolo(1,2-e)imidazole-1,3-dione UNII-9BLW27W4X7 BMS-564,929，CAS 627530-84-1），分子式 C14H12ClN3O3，分子量 305.72。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-Chloro-3-methyl-4-(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo1,2-<I>c</I>imidazol-2(3<I>H</I>)-ylbenzonitrile在内的目标物的控制。 CAS编号 627530-84-1 对应的化合物2-Chloro-3-methyl-4-(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo1,2-<I>c</I>imidazol-2(3<I>H</I>)-ylbenzonitrile（英文标识 627530-84-1 9BLW27W4X7 BMS-564929 BMS 564929 (7R,7aS)-2-(3-Chloro-4-cyano-2-methylphenyl)-7-hydroxytetrahydro-2H-pyrrolo(1,2-e)imidazole-1,3-d

应用场景：在化学分析实验室中，2-Chloro-3-methyl-4- (7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo 1,2-<I>c</I> imidazol-2(3<I>H</I>)-yl benzonitrile（CAS 627530-84-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以2-Chloro-3-methyl-4- (7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo 1,2

理化性质 Physical & Chemical Properties

中文名称2-Chloro-3-methyl-4-[(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo[1,2-<I>c</I>]imidazol-2(3<I>H</I>)-yl]benzonitrile
分子式C14H12ClN3O3
分子量305.72 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1985年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人林芳，陈志强，沈红梅. "一种2-Chloro-3-methyl-4-[(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo[1,2-<I>c</I>]imidazol-2(3<I>H</I>)-yl]benzonitrile的合成方法" [P]. 中国发明专利, 专利号 CN 111122328 B, 授权公告日 2023-09-07.
  2. Mueller T, Roberts E F, O'Brien P Q. "Method for the Synthesis of 627530-84-1 9BLW27W4X7 BMS-564929 BMS 564929 (7R,7aS)-2-(3-Chloro-4-cyano-2-methylphenyl)-7-hydroxytetrahydro-2H-pyrrolo(1,2-e)imidazole-1,3-dione UNII-9BLW27W4X7 BMS-564,929" [P]. US Patent, US 9489428 B2, 2015-02-19.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of 2-Chloro-3-methyl-4-[(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo[1,2-<I>c</I>]imidazol-2(3<I>H</I>)-yl]benzonitrile in Pharmaceutical Formulations". Talanta, 2023, 2385, (4), 1865-1889.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-Chloro-3-methyl-4-[(7<I>R</I>,7a<I>S</I>)-tetrahydro-7-hydroxy-1,3-dioxo-1<I>H</I>-pyrrolo[1,2-<I>c</I>]imidazol-2(3<I>H</I>)-yl]benzonitrile as an Impurity". Food Chem., 2025, 1053, 2084-2087.

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