苯基二环己基膦 CAS 6476-37-5

Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170

纯度 97%+现货药物标准品
CAS 号6476-37-5
分子式C18H33P
分子量280.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

苯基二环己基膦 Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170 CAS 6476-37-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品苯基二环己基膦（Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170，CAS 6476-37-5），分子式 C18H33P，分子量 280.43。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），苯基二环己基膦满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C18H33P 的苯基二环己基膦（Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170），其CAS登记号是 6476-37-5，分子量为 280.43 g/mol。 受分子结构中有机磷的影响，苯基二环己基膦表现为白色至类白色结晶性粉末。其固体形态的物理化学属性——包括280.43 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。由于碳链较长，脂溶性良好，该化合物在Octanol-Water分配系

应用场景：针对化学分析用途，苯基二环己基膦（Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170）是具有明确定量溯源的认证级对照品。 推荐以苯基二环己基膦配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。

理化性质 Physical & Chemical Properties

中文名称苯基二环己基膦
分子式C18H33P
分子量280.43 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.5
CAS登记年份（估）1958年

相关专利 Related Patents

  1. O'Brien P Q, Brown S R, Williams B T. "一种苯基二环己基膦的合成方法" [P]. US Patent, US 10565056 B2, 2019-08-22.
  2. Chen K W, Brown S R, Williams B T. "Method for the Synthesis of Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170" [P]. US Patent, US 9253884 B2, 2021-01-16.
  3. 发明人陈志强，钱学锋，黄志刚. "A Process for Preparing High-Purity Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170" [P]. 中国发明专利, 专利号 CN 111767282 A, 授权公告日 2021-10-14.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 苯基二环己基膦 in Pharmaceutical Formulations". Phytochemistry, 2010, 1678, 6174-6181.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 苯基二环己基膦 as an Impurity". Anal. Chem., 2023, 588, (7), 8341-8361.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of Dicyclohexylphenylphosphine 6476-37-5 DICYCLOHEXYL-PHENYL-PHOSPHANE;DICYCLOHEXYLPHENYLPHOSPHINE;PHENYLDICYCLOHEXYLPHOSPHINE;PHENYLPHOSPHINODICYCLOHEXANE;PHOSPHINE, DICYCLOHEXYLPHENYL- SC11170 Using HRMS and NMR". Biomed. Chromatogr., 2019, 1844, (3), 9983-10010.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate 苯基二环己基膦 Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2019, 1918, (11), 304-320.

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