3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸 CAS 68399-81-5

45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid NSC 610929 UNII-45Q4J0071U

纯度 97%+现货药物标准品
CAS 号68399-81-5
分子式C7H17NO7S
分子量259.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸 45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid NSC 610929 UNII-45Q4J0071U CAS 68399-81-5 结构式 Chemical Structure

产品介绍 Description

CAS 68399-81-5 对应的3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸（45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid NSC 610929 UNII-45Q4J0071U）为 CATO 佳途药物标准品产品线成员。分子式 C7H17NO7S，分子量 259.28。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

3-N-三(羟甲基)甲胺-2-羟基丙磺酸（45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid NSC 610929 UNII-45Q4J0071U），CAS注册编号 68399-81-5，化学分子式为 C7H17NO7S，分子量 259.28 g/mol。 依据分子式为 C7H17NO7S 的3-N-三(羟甲基)甲胺-2-羟基丙磺酸结构特征

应用场景：3- N-三(羟甲基)甲胺 -2-羟基丙磺酸（45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2

理化性质 Physical & Chemical Properties

中文名称3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸
分子式C7H17NO7S
分子量259.28 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.0
CAS登记年份（估）1976年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人冯建国，徐明华，林芳. "一种3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸的合成方法" [P]. 中国发明专利, 专利号 CN 117329654 B, 授权公告日 2023-09-28.
  2. 发明人徐明华，王建平，刘建华. "Method for the Synthesis of 45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid NSC 610929 UNII-45Q4J0071U" [P]. 中国发明专利, 专利号 CN 115350935 B, 授权公告日 2018-08-13.
  3. Thompson G K, Lee S K, Kumar R. "A Process for Preparing High-Purity 45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid NSC 610929 UNII-45Q4J0071U" [P]. US Patent, US 10408478 B2, 2021-08-18.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸 in Pharmaceutical Formulations". Biomed. Chromatogr., 2012, 1559, (4), 8515-8539.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸 as an Impurity". Rapid Commun. Mass Spectrom., 2015, 1941, 6922-6939.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 45Q4J0071U 68399-81-5 N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid 2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid 1-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)- EINECS 269-993-8 3-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid NSC 610929 UNII-45Q4J0071U Using HRMS and NMR". Environ. Sci. Technol., 2014, 1802, (11), 7632-7652.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate 3-[N-三(羟甲基)甲胺]-2-羟基丙磺酸 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2023, 2172, (11), 9223-9247.

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