CAS 6857-88-1
(3aS,5aS,6R,9aR,9bS)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid 4-Nor-3,5-seco-5,17-dioxoandrostan-3-oic Acid 5,17-Dioxo-3,5-seco-A-norandrostan-3-oic Acid 6857-88-1 [3aS-(3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid
| CAS 号 | 6857-88-1 |
| 分子式 | C18H26O4 |
| 分子量 | 306.40 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
（(3aS,5aS,6R,9aR,9bS)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid 4-Nor-3,5-seco-5,17-dioxoandrostan-3-oic Acid 5,17-Dioxo-3,5-seco-A-norandrostan-3-oic Acid 6857-88-1 [3aS-(3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid，CAS 号 6857-88-1）是 CATO 佳途自主生产的药物标准品，分子式 C18H26O4，分子量 306.40。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
的产生途径与其化学式中甾体骨架，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 （(3aS,5aS,6R,9aR,9bS)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benzeindene-6-propanoic Acid 4-Nor-3,5-seco-5,17-dioxoandrostan-3-oic Acid 5,17-Dioxo-3,5-seco-A-norandrostan-3-oic Acid 6857-88-1 3aS-(3a|A,5a|A,6|A,9a|A,9b|A)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benzeindene-6-propanoic Acid），CAS注册编号 6857-88-1，化学分子式为 C18H26O4，分子量 306.40 g/mol。 依据分子式为 C18H26O4 的结构特征，其分子内含甾体骨架，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 306.40 g/mol 这一参数对质谱检
应用场景：针对化学分析用途，（(3aS,5aS,6R,9aR,9bS)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz e indene-6-propanoic Acid 4-Nor-3,5-seco-5,17-dioxoandrostan-3-oic Acid 5,17-Dioxo-3,5-seco-A-norandrostan-3-oic Acid 6857-88-1 3aS-(3a|A,5a|A,6|A,9a|A,9b|A) -Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz e indene-6-propanoic
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C18H26O4 |
| 分子量 | 306.40 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 6.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1958年 |
相关专利 Related Patents
- 发明人唐晓军，胡光，张德明. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 112810887 A, 授权公告日 2016-04-13.
- 发明人徐明华，冯建国，何建平. "Method for the Synthesis of (3aS,5aS,6R,9aR,9bS)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid 4-Nor-3,5-seco-5,17-dioxoandrostan-3-oic Acid 5,17-Dioxo-3,5-seco-A-norandrostan-3-oic Acid 6857-88-1 [3aS-(3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid" [P]. 中国发明专利, 专利号 CN 112533081 B, 授权公告日 2023-09-13.
- 发明人陈志强，沈红梅，郭海燕. "A Process for Preparing High-Purity (3aS,5aS,6R,9aR,9bS)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid 4-Nor-3,5-seco-5,17-dioxoandrostan-3-oic Acid 5,17-Dioxo-3,5-seco-A-norandrostan-3-oic Acid 6857-88-1 [3aS-(3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid" [P]. 中国发明专利, 专利号 CN 109916063 B, 授权公告日 2017-01-15.
参考文献 Literature
- Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Sep. Sci., 2013, 1649, 6484-6498.
- Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Chromatographia, 2025, 680, (9), 9677-9692.
- Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of (3aS,5aS,6R,9aR,9bS)-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid 4-Nor-3,5-seco-5,17-dioxoandrostan-3-oic Acid 5,17-Dioxo-3,5-seco-A-norandrostan-3-oic Acid 6857-88-1 [3aS-(3a|A,5a|A,6|A,9a|A,9b|A)]-Dodecahydro-3a,6-dimethyl-3,7-dioxo-1H-benz[e]indene-6-propanoic Acid Using HRMS and NMR". Biomed. Chromatogr., 2022, 1777, 2668-2680.
- Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2015, 82, 7485-7506.
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