Trizma<SUP>®</SUP> 磷酸盐 一元 CAS 6992-39-8

(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(tris[hydroxymethyl]aminomethane) phosphate tris phosphate

纯度 97%+现货药物标准品
CAS 号6992-39-8
分子式C4H11NO3 H3O4P
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Trizma<SUP>®</SUP> 磷酸盐 一元 (2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(tris[hydroxymethyl]aminomethane) phosphate tris phosphate CAS 6992-39-8 结构式 Chemical Structure

产品介绍 Description

Trizma<SUP>®</SUP> 磷酸盐 一元（英文名 (2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(tris[hydroxymethyl]aminomethane) phosphate tris phosphate，CAS 6992-39-8）属于药物标准品。分子式 C4H11NO3 H3O4P。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 Trizma<SUP>®</SUP> 磷酸盐 一元（(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(trishydroxymethylaminomethane) phosphate tris phosphate），CAS注册编号 6992-39-8，化学分子式为 C4H11NO3 H3O4P，分子量 219.13 g/mol。 Trizma<SUP>®</SUP> 磷酸盐 一元（C4H11NO3 H3O4P）含有糖类衍生物，酰胺类，含磷酸酯基。具有较强的吸湿性，羧基赋予其一

应用场景：Trizma<SUP>®</SUP> 磷酸盐 一元（(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(tris hydroxymethyl aminomethane) phosphate tris phosphate

理化性质 Physical & Chemical Properties

中文名称Trizma<SUP>®</SUP> 磷酸盐 一元
分子式C4H11NO3 H3O4P
分子量219.13 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）-1.5
CAS登记年份（估）1958年
含氮原子数1

相关专利 Related Patents

  1. 发明人徐明华，郑宇鹏，韩伟. "一种Trizma<SUP>®</SUP> 磷酸盐 一元的合成方法" [P]. 中国发明专利, 专利号 CN 108831098 A, 授权公告日 2021-11-01.
  2. 发明人韩伟，高志强，林芳. "Method for the Synthesis of (2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(tris[hydroxymethyl]aminomethane) phosphate tris phosphate" [P]. 中国发明专利, 专利号 CN 111931163 B, 授权公告日 2022-04-03.
  3. Björnsson E, Martínez F, Kowalski A. "A Process for Preparing High-Purity (2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(tris[hydroxymethyl]aminomethane) phosphate tris phosphate" [P]. European Patent, EP 3787798 A1, 2025-03-18.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of Trizma<SUP>®</SUP> 磷酸盐 一元 in Pharmaceutical Formulations". Sci. Total Environ., 2025, 2359, 6474-6490.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of Trizma<SUP>®</SUP> 磷酸盐 一元 as an Impurity". Anal. Chem., 2017, 1772, 5061-5090.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)ammonium dihydrogen phosphate 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium dihydrogen phosphate 2-amino-2-(hydroxymethyl)propane-1,3-diol phosphate 6992-39-8 CHEBI:67098 mono(tris[hydroxymethyl]aminomethane) phosphate tris phosphate Using HRMS and NMR". Talanta, 2017, 358, (3), 5433-5443.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Trizma<SUP>®</SUP> 磷酸盐 一元 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2020, 993, 8325-8328.

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