α-甲氧基苯乙酸 CAS 7021-09-2
7021-09-2 MAT0P17A95 alpha-Methoxyphenylacetic acid Acetic acid, methoxyphenyl- (8CI) Benzeneacetic acid, alpha-methoxy- Methoxy(phenyl)acetic acid (1)-(Methoxy)phenylacetic acid AI3-19941 EINECS 216-933-3 EINECS 230-300-9 MOPA NSC 5665 DL-alpha-Methoxyphenylacetic acid DL-Methoxyphenylacetic acid Methoxyphenylacetic acid (RS)-alpha-Methoxyphenylacetic acid UNII-MAT0P17A95 (+/-)-2-Methoxy-2-phenylacetic acid (+/-)-alpha-Methoxyphenylacetic acid
| CAS 号 | 7021-09-2 |
| 分子式 | C9H16O3 |
| 分子量 | 172.22 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品α-甲氧基苯乙酸（7021-09-2 MAT0P17A95 alpha-Methoxyphenylacetic acid Acetic acid, methoxyphenyl- (8CI) Benzeneacetic acid, alpha-methoxy- Methoxy(phenyl)acetic acid (1)-(Methoxy)phenylacetic acid AI3-19941 EINECS 216-933-3 EINECS 230-300-9 MOPA NSC 5665 DL-alpha-Methoxyphenylacetic acid DL-Methoxyphenylacetic acid Methoxyphenylacetic acid (RS)-alpha-Methoxyphenylacetic acid UNII-MAT0P17A95 (+/-)-2-Methoxy-2-phenylacetic acid (+/-)-alpha-Methoxyphenylacetic acid，CAS 7021-09-2），分子式 C9H16O3，分子量 172.22。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 7021-09-2 对应的化合物α-甲氧基苯乙酸（英文标识 7021-09-2 MAT0P17A95 alpha-Methoxyphenylacetic acid Acetic acid, methoxyphenyl- (8CI) Benzeneacetic acid, alpha-methoxy- Methoxy(phenyl)acetic acid (1)-(Methoxy)phenylacetic acid AI3-19941 EINECS 216-933-3 EINECS 230-300-9 MOPA NSC 5665 DL-alpha-Methoxyphenylacetic acid DL-Methoxyphenylacetic acid Methoxyphenylacetic acid (RS)-alpha-Methoxyphenylacetic acid UNII-MAT0P17A95 (+/-)-2-Methoxy-
应用场景：在化学分析实验室中，α-甲氧基苯乙酸（CAS 7021-09-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以α-甲氧基苯乙酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | α-甲氧基苯乙酸 |
| 分子式 | C9H16O3 |
| 分子量 | 172.22 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1959年 |
相关专利 Related Patents
- Hughes D C, Park J H, Kumar R. "一种α-甲氧基苯乙酸的合成方法" [P]. US Patent, US 11608036 B2, 2024-11-05.
- Roberts E F, Williams B T, Hughes D C. "Method for the Synthesis of 7021-09-2 MAT0P17A95 alpha-Methoxyphenylacetic acid Acetic acid, methoxyphenyl- (8CI) Benzeneacetic acid, alpha-methoxy- Methoxy(phenyl)acetic acid (1)-(Methoxy)phenylacetic acid AI3-19941 EINECS 216-933-3 EINECS 230-300-9 MOPA NSC 5665 DL-alpha-Methoxyphenylacetic acid DL-Methoxyphenylacetic acid Methoxyphenylacetic acid (RS)-alpha-Methoxyphenylacetic acid UNII-MAT0P17A95 (+/-)-2-Methoxy-2-phenylacetic acid (+/-)-alpha-Methoxyphenylacetic acid" [P]. US Patent, US 10371284 B2, 2016-07-23.
- 发明人马晓峰，沈红梅，郑宇鹏. "A Process for Preparing High-Purity 7021-09-2 MAT0P17A95 alpha-Methoxyphenylacetic acid Acetic acid, methoxyphenyl- (8CI) Benzeneacetic acid, alpha-methoxy- Methoxy(phenyl)acetic acid (1)-(Methoxy)phenylacetic acid AI3-19941 EINECS 216-933-3 EINECS 230-300-9 MOPA NSC 5665 DL-alpha-Methoxyphenylacetic acid DL-Methoxyphenylacetic acid Methoxyphenylacetic acid (RS)-alpha-Methoxyphenylacetic acid UNII-MAT0P17A95 (+/-)-2-Methoxy-2-phenylacetic acid (+/-)-alpha-Methoxyphenylacetic acid" [P]. 中国发明专利, 专利号 CN 115936059 A, 授权公告日 2018-03-28.
参考文献 Literature
- Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of α-甲氧基苯乙酸 in Pharmaceutical Formulations". Chromatographia, 2023, 226, 8901-8915.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of α-甲氧基苯乙酸 as an Impurity". J. Agric. Food Chem., 2024, 1171, 2026-2038.
- Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of 7021-09-2 MAT0P17A95 alpha-Methoxyphenylacetic acid Acetic acid, methoxyphenyl- (8CI) Benzeneacetic acid, alpha-methoxy- Methoxy(phenyl)acetic acid (1)-(Methoxy)phenylacetic acid AI3-19941 EINECS 216-933-3 EINECS 230-300-9 MOPA NSC 5665 DL-alpha-Methoxyphenylacetic acid DL-Methoxyphenylacetic acid Methoxyphenylacetic acid (RS)-alpha-Methoxyphenylacetic acid UNII-MAT0P17A95 (+/-)-2-Methoxy-2-phenylacetic acid (+/-)-alpha-Methoxyphenylacetic acid Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2022, 740, (12), 2119-2147.
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