Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH CAS 706806-64-6

(2R)-1-tert-butoxycarbonyl-2-(4-fluorobenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 706806-64-6 Boc-(R)-alpha-(4-fluorobenzyl)-proline

纯度 97%+现货药物标准品
CAS 号706806-64-6
分子式C17H28FNO4
分子量329.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH (2R)-1-tert-butoxycarbonyl-2-(4-fluorobenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 706806-64-6 Boc-(R)-alpha-(4-fluorobenzyl)-proline CAS 706806-64-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH（(2R)-1-tert-butoxycarbonyl-2-(4-fluorobenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 706806-64-6 Boc-(R)-alpha-(4-fluorobenzyl)-proline）为药物标准品，CAS 登记号 706806-64-6，分子式 C17H28FNO4，分子量 329.41。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 706806-64-6 对应的化合物Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH（英文标识 (2R)-1-tert-butoxycarbonyl-2-(4-fluorobenzyl)proline (2R)-1-tert-butoxycarbonyl-2-(4-fluorophenyl)methylpyrrolidine-2-carboxylic acid (2R)-2-(4-fluorophenyl)methyl-1-(2-methylpropan-2-yl)oxy-oxomethyl-2-pyrrolidinecarboxylic acid (2R)-2-(4-fluorophenyl)methyl-1-(2-methylpropan-2-yl)oxycarbonylpyrrolidine-2-carboxylic acid 706806-64-6 Boc-(R)-alpha-(4-fluo

应用场景：在化学分析实验室中，Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH（CAS 706806-64-6）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制

理化性质 Physical & Chemical Properties

中文名称Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH
分子式C17H28FNO4
分子量329.41 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1985年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. Martínez F, Lefèvre J P, Rossi M. "一种Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH的合成方法" [P]. European Patent, EP 3657744 A1, 2020-07-24.
  2. Sørensen M, Nielsen H, Björnsson E. "Method for the Synthesis of (2R)-1-tert-butoxycarbonyl-2-(4-fluorobenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 706806-64-6 Boc-(R)-alpha-(4-fluorobenzyl)-proline" [P]. European Patent, EP 3306551 A1, 2022-11-28.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH in Pharmaceutical Formulations". Talanta, 2017, 1761, 4230-4258.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH as an Impurity". Anal. Chim. Acta, 2012, 1736, (9), 991-1014.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of (2R)-1-tert-butoxycarbonyl-2-(4-fluorobenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-fluorophenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 706806-64-6 Boc-(R)-alpha-(4-fluorobenzyl)-proline Using HRMS and NMR". J. Pharm. Biomed. Anal., 2014, 125, (11), 8419-8430.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate Boc-<I>(R)</I>-α-(4-氟苄基)-Pro-OH Profile in Drug Substances According to ICH Guidelines". Molecules, 2019, 1761, (8), 9428-9438.

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