2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one CAS 728908-04-1

2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

纯度 97%+现货药物标准品
CAS 号728908-04-1
分子式C12H13ClN2OS
分子量268.76 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one CAS 728908-04-1 结构式 Chemical Structure

产品介绍 Description

CAS 728908-04-1 对应的2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one（2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one）为 CATO 佳途药物标准品产品线成员。分子式 C12H13ClN2OS，分子量 268.76。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo4,5thieno2,3-dpyrimidin-4-one的产生途径与其化学式中含氮杂环结构，酰胺类，含硫有机，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 728908-04-1 对应的化合物2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo4,5thieno2,3-dpyrimidin-4-one（英文标识 2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo4,5thieno2,3-dpyrimidin-4-one），化学式 C12H13ClN2OS，相对分子质量 268.76。 2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo4,5thieno2,3-dpyrimidin-4-one（C12H13ClN2OS）含有含氮杂环结构，

应用场景：2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo 4,5 thieno 2,3-d pyrimidin-4-one（2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo 4,5 thieno 2,3-d pyrimidin-4-one，CAS 728908-04-1）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo 4,5 thieno 2,3-d pyrimidin-4-one配

理化性质 Physical & Chemical Properties

中文名称2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one
分子式C12H13ClN2OS
分子量268.76 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
卤素含量Cl取代
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. 发明人徐明华，黄志刚，杨光. "一种2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one的合成方法" [P]. 中国发明专利, 专利号 CN 115923220 B, 授权公告日 2019-11-21.
  2. 发明人韩伟，高志强，赵玉洁. "Method for the Synthesis of 2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one" [P]. 中国发明专利, 专利号 CN 108743337 A, 授权公告日 2016-02-20.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one in Pharmaceutical Formulations". J. Sep. Sci., 2015, 975, (12), 9698-9702.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one as an Impurity". Phytochemistry, 2011, 778, (8), 422-427.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 2-Chloromethyl-7-methyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one Using HRMS and NMR". Biomed. Chromatogr., 2012, 485, 1977-1993.

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