14-脱甲基-羊毛甾醇 CAS 7448-02-4

7448-02-4 14-demethyllanosterol 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethylzymosterol (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol 14-desmethyllanosterol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol 4,4-Dimethyl-8,24-cholestadienol CHEBI:18364

纯度 97%+现货药物标准品
CAS 号7448-02-4
分子式C29H48O
分子量412.69 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

14-脱甲基-羊毛甾醇 7448-02-4 14-demethyllanosterol 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethylzymosterol (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol 14-desmethyllanosterol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol 4,4-Dimethyl-8,24-cholestadienol CHEBI:18364 CAS 7448-02-4 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品14-脱甲基-羊毛甾醇（7448-02-4 14-demethyllanosterol 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethylzymosterol (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol 14-desmethyllanosterol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol 4,4-Dimethyl-8,24-cholestadienol CHEBI:18364，CAS 7448-02-4），分子式 C29H48O，分子量 412.69。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在质量保证方面，14-脱甲基-羊毛甾醇的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 7448-02-4 对应的化合物14-脱甲基-羊毛甾醇（英文标识 7448-02-4 14-demethyllanosterol 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethylzymosterol (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol 14-desmethyllanosterol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol 4,4-Dimethyl-8,24-cholestadienol CHEBI:18364），化学式 C29H48O，相对分子质量 412.69。 从化学结构特征来看，14

应用场景：针对化学分析用途，14-脱甲基-羊毛甾醇（7448-02-4 14-demethyllanosterol 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethylzymosterol (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol 14-desmethyllanosterol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol 4,4-Dimethyl-8,24-cholestadienol CHEBI:18364）是具有明确定量溯源的认证级对

理化性质 Physical & Chemical Properties

中文名称14-脱甲基-羊毛甾醇
分子式C29H48O
分子量412.69 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1959年

相关专利 Related Patents

  1. 发明人韩伟，何建平，郭海燕. "一种14-脱甲基-羊毛甾醇的合成方法" [P]. 中国发明专利, 专利号 CN 111983657 B, 授权公告日 2025-07-24.
  2. Brown S R, Fischer A B, Yamamoto T. "Method for the Synthesis of 7448-02-4 14-demethyllanosterol 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethylzymosterol (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol 14-desmethyllanosterol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol 4,4-Dimethyl-8,24-cholestadienol CHEBI:18364" [P]. US Patent, US 11070041 B2, 2019-08-09.
  3. Thompson G K, Brown S R, Mueller T. "A Process for Preparing High-Purity 7448-02-4 14-demethyllanosterol 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethylzymosterol (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol 14-desmethyllanosterol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol 4,4-Dimethyl-8,24-cholestadienol CHEBI:18364" [P]. US Patent, US 10998920 B2, 2015-02-14.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 14-脱甲基-羊毛甾醇 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2015, 464, 2658-2668.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 14-脱甲基-羊毛甾醇 as an Impurity". Molecules, 2023, 913, (2), 7583-7611.

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