5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol CAS 748778-16-7

5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol

纯度 97%+现货药物标准品
CAS 号748778-16-7
分子式C19H21N3OS
分子量339.45 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol CAS 748778-16-7 结构式 Chemical Structure

产品介绍 Description

CAS 748778-16-7 对应的5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol（5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol）为 CATO 佳途药物标准品产品线成员。分子式 C19H21N3OS，分子量 339.45。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-1,2,4triazole-3-thiol（5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-1,2,4triazole-3-thiol），CAS注册编号 748778-16-7，化学分子式为 C19H21N3OS，分子量 339.45 g/mol。 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-1,2,4triazole-3-thiol（C19H21N3OS）含有甾体骨架，酰胺类，含硫有机，含羟基，含醚键。较高的碳氢比使其脂溶性较好，这些物理化学性质直接决定了其标

应用场景：5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H- 1,2,4 triazole-3-thiol（5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H- 1,2,4 triazole-3-thiol，CAS 748778-16-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H- 1,2,4 triazole-3-thiol配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:

理化性质 Physical & Chemical Properties

中文名称5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol
分子式C19H21N3OS
分子量339.45 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. Chen K W, Fischer A B, Schröder R. "一种5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol的合成方法" [P]. US Patent, US 10558803 B2, 2023-04-18.
  2. Lee S K, Mueller T, Brown S R. "Method for the Synthesis of 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol" [P]. US Patent, US 9551957 B2, 2025-09-17.
  3. 发明人沈红梅，钱学锋，郭海燕. "A Process for Preparing High-Purity 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol" [P]. 中国发明专利, 专利号 CN 112152378 A, 授权公告日 2017-06-11.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol in Pharmaceutical Formulations". J. Nat. Prod., 2016, 2208, (4), 496-512.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol as an Impurity". J. Sep. Sci., 2012, 952, 6382-6407.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 5-(4-Ethyl-phenoxymethyl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazole-3-thiol Using HRMS and NMR". Biomed. Chromatogr., 2018, 499, (6), 2818-2834.

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