发明人钱学锋,高志强,赵玉洁. "Method for the Synthesis of 75410-53-6
Echinoside A
Lanost-9(11)-en-18-oic acid, 12,17,20-trihydroxy-3-((O-3-O-methyl-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-4)-O-6-deoxy-beta-D-glucopyranosyl-(1-2)-4-O-sulfo-beta-D-xylopyranosyl)oxy)-, gamma-lactone, monosodium salt, (3beta,12alpha)-
Holothurin A2
(3beta,12alpha)-12,17,20-Trihydroxy-3-((O-3-O-methyl-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-4)-O-6-deoxy-beta-D-glucopyranosyl-(1-2)-4-O-sulfo-beta-D-xylopyranosyl)-oxy)lanost-9(11)-en-18-oic acid gamma-lactone, monosodium salt" [P]. 中国发明专利, 专利号 CN 115842360 B, 授权公告日 2022-02-18.
Rossi M, Nielsen H, Sørensen M. "A Process for Preparing High-Purity 75410-53-6
Echinoside A
Lanost-9(11)-en-18-oic acid, 12,17,20-trihydroxy-3-((O-3-O-methyl-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-4)-O-6-deoxy-beta-D-glucopyranosyl-(1-2)-4-O-sulfo-beta-D-xylopyranosyl)oxy)-, gamma-lactone, monosodium salt, (3beta,12alpha)-
Holothurin A2
(3beta,12alpha)-12,17,20-Trihydroxy-3-((O-3-O-methyl-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-4)-O-6-deoxy-beta-D-glucopyranosyl-(1-2)-4-O-sulfo-beta-D-xylopyranosyl)-oxy)lanost-9(11)-en-18-oic acid gamma-lactone, monosodium salt" [P]. European Patent, EP 3912176 A1, 2018-09-01.
参考文献 Literature
Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of Echinoside A in Pharmaceutical Formulations". Chromatographia, 2019, 999, (10), 2077-2104.
Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of Echinoside A as an Impurity". Rapid Commun. Mass Spectrom., 2014, 1214, 7704-7725.
Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 75410-53-6
Echinoside A
Lanost-9(11)-en-18-oic acid, 12,17,20-trihydroxy-3-((O-3-O-methyl-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-4)-O-6-deoxy-beta-D-glucopyranosyl-(1-2)-4-O-sulfo-beta-D-xylopyranosyl)oxy)-, gamma-lactone, monosodium salt, (3beta,12alpha)-
Holothurin A2
(3beta,12alpha)-12,17,20-Trihydroxy-3-((O-3-O-methyl-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-4)-O-6-deoxy-beta-D-glucopyranosyl-(1-2)-4-O-sulfo-beta-D-xylopyranosyl)-oxy)lanost-9(11)-en-18-oic acid gamma-lactone, monosodium salt Using HRMS and NMR". Environ. Sci. Technol., 2013, 1423, 4131-4151.