[3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮 CAS 76855-69-1

(1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldimethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone 76855-69-1 [3R(1 inverted exclamation markaR,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone [3R-[3|A(R*),4|A]]-4-(Acetyloxy)-3-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-azetidinone

纯度 97%+现货药物标准品
CAS 号76855-69-1
分子式C13H25NO4Si
分子量287.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮 (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldimethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone 76855-69-1 [3R(1 inverted exclamation markaR,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone [3R-[3|A(R*),4|A]]-4-(Acetyloxy)-3-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-azetidinone CAS 76855-69-1 结构式 Chemical Structure

产品介绍 Description

[3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮（(1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldimethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone 76855-69-1 [3R(1 inverted exclamation markaR,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone [3R-[3|A(R*),4|A]]-4-(Acetyloxy)-3-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-azetidinone，CAS 号 76855-69-1）是 CATO 佳途自主生产的药物标准品，分子式 C13H25NO4Si，分子量 287.43。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，3<I>R</I>(1′<I>R</I>,4<I>R</I>)-(+)-4-乙酰氧基-3-1-(叔丁基二甲基硅氧基)乙基-2-氮杂环丁酮的分子量为287.43 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 76855-69-1 对应的化合物3<I>R</I>(1′<I>R</I>,4<I>R</I>)-(+)-4-乙酰氧基-3-1-(叔丁基二甲基硅氧基)乙基-2-氮杂环丁酮（英文标识 (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldimethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-(R)-1-(tert-butyldimethylsiloxy)ethylazetidin-2-one (3R,4R)-4-Acetoxy-3-(R)-1-(tert-butyldimethylsilyloxy)ethyl-2-azetidinone (3R,4R)-4-Acetoxy-3-(R)-1-(tert-butyldimet

应用场景：在化学分析实验室中， 3<I>R</I>(1′<I>R</I>,4<I>R</I>) -(+)-4-乙酰氧基-3- 1-(叔丁基二甲基硅氧基)乙基 -2-氮杂环丁酮（CAS 76855-69-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以 3<I>R</I>(1′<I>R</I>,4<I>R</I>) -(+)-4-乙酰氧基-3- 1-(叔丁基二甲基硅氧基)乙基 -2-氮杂环丁酮配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温

理化性质 Physical & Chemical Properties

中文名称[3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮
分子式C13H25NO4Si
分子量287.43 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1978年
含氮原子数1

相关专利 Related Patents

  1. Björnsson E, Nowak P, Schröder R. "一种[3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮的合成方法" [P]. European Patent, EP 3293544 A1, 2020-11-03.
  2. 发明人郭海燕，黄志刚，冯建国. "Method for the Synthesis of (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldimethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone 76855-69-1 [3R(1 inverted exclamation markaR,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone [3R-[3|A(R*),4|A]]-4-(Acetyloxy)-3-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-azetidinone" [P]. 中国发明专利, 专利号 CN 111337681 A, 授权公告日 2024-05-14.
  3. Martínez F, Björnsson E, Nowak P. "A Process for Preparing High-Purity (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldimethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone 76855-69-1 [3R(1 inverted exclamation markaR,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone [3R-[3|A(R*),4|A]]-4-(Acetyloxy)-3-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-azetidinone" [P]. European Patent, EP 3165321 A1, 2024-01-17.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of [3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮 in Pharmaceutical Formulations". Phytochemistry, 2017, 286, (6), 8775-8804.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of [3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮 as an Impurity". Rapid Commun. Mass Spectrom., 2021, 400, (9), 521-544.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldimethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone 76855-69-1 [3R(1 inverted exclamation markaR,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone [3R-[3|A(R*),4|A]]-4-(Acetyloxy)-3-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-azetidinone Using HRMS and NMR". Biomed. Chromatogr., 2011, 1193, (3), 7903-7922.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate [3<I>R</I>(1′<I>R</I>,4<I>R</I>)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2019, 1577, 9660-9684.

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