S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯 CAS 76931-93-6

76931-93-6 Ethanethioic Acid S-[2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] Ester N-Succinimidyl (acetylthio)acetate N-Succinimidyl S-acetylthioglycolate N-Succinimidyl-S-acetylthioacetate S-Acetylthioglycolic acid N-hydroxysuccinimide ester S-Acetylthioglycolic acid NHS ester SATA

纯度 97%+现货药物标准品
CAS 号76931-93-6
分子式C8H9NO5S
分子量231.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯 76931-93-6 Ethanethioic Acid S-[2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] Ester N-Succinimidyl (acetylthio)acetate N-Succinimidyl S-acetylthioglycolate N-Succinimidyl-S-acetylthioacetate S-Acetylthioglycolic acid N-hydroxysuccinimide ester S-Acetylthioglycolic acid NHS ester SATA CAS 76931-93-6 结构式 Chemical Structure

产品介绍 Description

S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯（76931-93-6 Ethanethioic Acid S-[2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] Ester N-Succinimidyl (acetylthio)acetate N-Succinimidyl S-acetylthioglycolate N-Succinimidyl-S-acetylthioacetate S-Acetylthioglycolic acid N-hydroxysuccinimide ester S-Acetylthioglycolic acid NHS ester SATA，CAS 号 76931-93-6）是 CATO 佳途自主生产的药物标准品，分子式 C8H9NO5S，分子量 231.23。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯的分子量为231.23 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 76931-93-6 对应的化合物S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯（英文标识 76931-93-6 Ethanethioic Acid S-2-(2,5-Dioxo-1-pyrrolidinyl)oxy-2-oxoethyl Ester N-Succinimidyl (acetylthio)acetate N-Succinimidyl S-acetylthioglycolate N-Succinimidyl-S-acetylthioacetate S-Acetylthioglycolic acid N-hydroxysuccinimide ester S-Acetylthioglycolic acid NHS ester SATA），化学式 C8H9NO5S，相对分子质量 231.23。 受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键的影响，S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯表现为类白色至淡

应用场景：S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯（76931-93-6 Ethanethioic Acid S- 2- (2,5-Dioxo-1-pyrrolidinyl)oxy -2-oxoethyl Ester N-Succinimidyl (acetylthio)acetate N-Succinimidyl S-acetylthioglycolate N-Succinimidyl-S-acetylthioacetate S-Acetylthioglycolic acid N-hydroxysuccinimide ester S-Acetylthioglycolic acid NHS ester

理化性质 Physical & Chemical Properties

中文名称S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯
分子式C8H9NO5S
分子量231.23 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1978年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人沈红梅，冯建国，高志强. "一种S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯的合成方法" [P]. 中国发明专利, 专利号 CN 113060097 B, 授权公告日 2023-10-17.
  2. 发明人高志强，钱学锋，徐明华. "Method for the Synthesis of 76931-93-6 Ethanethioic Acid S-[2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] Ester N-Succinimidyl (acetylthio)acetate N-Succinimidyl S-acetylthioglycolate N-Succinimidyl-S-acetylthioacetate S-Acetylthioglycolic acid N-hydroxysuccinimide ester S-Acetylthioglycolic acid NHS ester SATA" [P]. 中国发明专利, 专利号 CN 117871294 B, 授权公告日 2022-07-12.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯 in Pharmaceutical Formulations". Anal. Chem., 2018, 103, (11), 898-912.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯 as an Impurity". Rapid Commun. Mass Spectrom., 2015, 1711, 4569-4573.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 76931-93-6 Ethanethioic Acid S-[2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] Ester N-Succinimidyl (acetylthio)acetate N-Succinimidyl S-acetylthioglycolate N-Succinimidyl-S-acetylthioacetate S-Acetylthioglycolic acid N-hydroxysuccinimide ester S-Acetylthioglycolic acid NHS ester SATA Using HRMS and NMR". Food Chem., 2017, 505, (6), 3558-3567.

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