(6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid CAS 79350-22-4

(6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

纯度 97%+现货药物标准品
CAS 号79350-22-4
分子式C15H12N4O6S2
分子量408.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid CAS 79350-22-4 结构式 Chemical Structure

产品介绍 Description

CAS 79350-22-4 对应的(6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid（(6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid）为 CATO 佳途药物标准品产品线成员。分子式 C15H12N4O6S2，分子量 408.41。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

从化学结构特征来看，(6R-trans)-3-Ethenyl-7-2-(formylamino)-4-thiazolyloxoacetylamino-8-oxo-5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic Acid的分子骨架中包含黄酮骨架，酰胺类，含砜基，含羟基，含醚键。该化合物的不饱和度为12.0，表明结构中存在约12个环或双键等价单元。分子量为408.41 g/mol，属于较高分子量化合物。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 (6R-trans)-3-Ethenyl-7-2-(formylamino)-4-thiazolyloxoacetylamino-8-oxo-5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic Acid（(6R-trans)-3-Ethenyl-7-2-(formylamino)-4-thiazolyloxoacetylamino-8-oxo-5-Thia-1-azabicyclo

应用场景：针对化学分析用途，(6R-trans)-3-Ethenyl-7- 2-(formylamino)-4-thiazolyl oxoacetyl amino -8-oxo-5-Thia-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic Acid（(6R-trans)-3-Ethenyl-7- 2-(formylamino)-4-thiazolyl oxoacetyl amino -8-oxo-5-Thia-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic Acid）是具有明确定量溯源的认证级对照品。 推荐以(6R-tra

理化性质 Physical & Chemical Properties

中文名称(6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
分子式C15H12N4O6S2
分子量408.41 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1979年
含氮原子数4
含硫原子数2

相关专利 Related Patents

  1. 发明人胡光，高志强，钱学锋. "一种(6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid的合成方法" [P]. 中国发明专利, 专利号 CN 109493226 B, 授权公告日 2016-12-07.
  2. 发明人林芳，钱学锋，罗永刚. "Method for the Synthesis of (6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid" [P]. 中国发明专利, 专利号 CN 115884561 A, 授权公告日 2019-08-14.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of (6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid in Pharmaceutical Formulations". Environ. Sci. Technol., 2016, 472, (5), 6721-6726.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of (6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid as an Impurity". Anal. Methods, 2018, 166, (5), 7394-7423.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of (6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Using HRMS and NMR". J. Sep. Sci., 2017, 2274, (7), 2554-2565.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate (6R-trans)-3-Ethenyl-7-[[[2-(formylamino)-4-thiazolyl]oxoacetyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2010, 1619, (12), 4274-4277.

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