三异丙基硅基三氟甲烷磺酸酯 CAS 80522-42-5
Triisopropylsilyl trifluoromethanesulfonate Triisopropylsilyl triflate Trifluoromethanesulphonic acid triisopropylsilyl ester trifluoromethanesulfonic acid triisopropylsilyl ester triisopropylsilyl trifluoromethanesulphonate triisopropylsilyl-trifluoromethanesulfonate tri-iso-propylsilyl trifluoromethane sulfonate triisopropylsilyltrifluoromethanesulfonate 80522-42-5
| CAS 号 | 80522-42-5 |
| 分子式 | C10H21F3O3SSi |
| 分子量 | 306.42 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
三异丙基硅基三氟甲烷磺酸酯（Triisopropylsilyl trifluoromethanesulfonate Triisopropylsilyl triflate Trifluoromethanesulphonic acid triisopropylsilyl ester trifluoromethanesulfonic acid triisopropylsilyl ester triisopropylsilyl trifluoromethanesulphonate triisopropylsilyl-trifluoromethanesulfonate tri-iso-propylsilyl trifluoromethane sulfonate triisopropylsilyltrifluoromethanesulfonate 80522-42-5，CAS 号 80522-42-5）是 CATO 佳途自主生产的药物标准品，分子式 C10H21F3O3SSi，分子量 306.42。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括三异丙基硅基三氟甲烷磺酸酯在内的目标物的控制。 化学式为 C10H21F3O3SSi 的三异丙基硅基三氟甲烷磺酸酯（Triisopropylsilyl trifluoromethanesulfonate Triisopropylsilyl triflate Trifluoromethanesulphonic acid triisopropylsilyl ester trifluoromethanesulfonic acid triisopropylsilyl ester triisopropylsilyl trifluoromethanesulphonate triisopropylsilyl-trifluoromethanesulfonate tri-iso-propylsilyl trifluoromethane sulfonate triisopropylsilyltrifluoromethanesulfonate 80522-42-5），其CAS登记号是 80522-42-5，分子量为 306.42 g/mol。
应用场景：针对化学分析用途，三异丙基硅基三氟甲烷磺酸酯（Triisopropylsilyl trifluoromethanesulfonate Triisopropylsilyl triflate Trifluoromethanesulphonic acid triisopropylsilyl ester trifluoromethanesulfonic acid triisopropylsilyl ester triisopropylsilyl trifluoromethanesulphonate triisopropylsilyl-trifluoromethanesulfonate tri-iso-
理化性质 Physical & Chemical Properties
| 中文名称 | 三异丙基硅基三氟甲烷磺酸酯 |
| 分子式 | C10H21F3O3SSi |
| 分子量 | 306.42 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | -1.0 |
| CAS登记年份（估） | 1980年 |
| 卤素含量 | F取代 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- Martínez F, Kowalski A, Björnsson E. "一种三异丙基硅基三氟甲烷磺酸酯的合成方法" [P]. European Patent, EP 3659510 A1, 2023-02-03.
- 发明人刘建华，杨光，胡光. "Method for the Synthesis of Triisopropylsilyl trifluoromethanesulfonate Triisopropylsilyl triflate Trifluoromethanesulphonic acid triisopropylsilyl ester trifluoromethanesulfonic acid triisopropylsilyl ester triisopropylsilyl trifluoromethanesulphonate triisopropylsilyl-trifluoromethanesulfonate tri-iso-propylsilyl trifluoromethane sulfonate triisopropylsilyltrifluoromethanesulfonate 80522-42-5" [P]. 中国发明专利, 专利号 CN 108932749 B, 授权公告日 2025-07-02.
- Johansson L, Lefèvre J P, Martínez F. "A Process for Preparing High-Purity Triisopropylsilyl trifluoromethanesulfonate Triisopropylsilyl triflate Trifluoromethanesulphonic acid triisopropylsilyl ester trifluoromethanesulfonic acid triisopropylsilyl ester triisopropylsilyl trifluoromethanesulphonate triisopropylsilyl-trifluoromethanesulfonate tri-iso-propylsilyl trifluoromethane sulfonate triisopropylsilyltrifluoromethanesulfonate 80522-42-5" [P]. European Patent, EP 3713342 A1, 2020-08-25.
参考文献 Literature
- Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 三异丙基硅基三氟甲烷磺酸酯 in Pharmaceutical Formulations". Molecules, 2018, 2349, (9), 2180-2193.
- Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 三异丙基硅基三氟甲烷磺酸酯 as an Impurity". Anal. Methods, 2010, 2269, 4365-4385.
- Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of Triisopropylsilyl trifluoromethanesulfonate Triisopropylsilyl triflate Trifluoromethanesulphonic acid triisopropylsilyl ester trifluoromethanesulfonic acid triisopropylsilyl ester triisopropylsilyl trifluoromethanesulphonate triisopropylsilyl-trifluoromethanesulfonate tri-iso-propylsilyl trifluoromethane sulfonate triisopropylsilyltrifluoromethanesulfonate 80522-42-5 Using HRMS and NMR". Food Chem., 2010, 1041, (8), 8775-8783.
- Kim S H, Park J Y. "Forced Degradation Studies to Evaluate 三异丙基硅基三氟甲烷磺酸酯 Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2024, 1135, (7), 789-799.
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