(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-[(2,2,3,3-四甲基环丙烷羰基)氧基]-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-17-甲酸(氰基甲基)酯 CAS 827319-43-7
Cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
| CAS 号 | 827319-43-7 |
| 分子式 | C31H39F2NO6 |
| 分子量 | 559.64 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-[(2,2,3,3-四甲基环丙烷羰基)氧基]-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-17-甲酸(氰基甲基)酯（英文名 Cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate，CAS 827319-43-7）属于药物标准品。分子式 C31H39F2NO6，分子量 559.64。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 827319-43-7 对应的化合物(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-(2,2,3,3-四甲基环丙烷羰基)氧基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并a菲-17-甲酸(氰基甲基)酯（英文标识 Cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopentaaphenanthrene-17-carboxylate），化学式 C31H39F2
应用场景：在化学分析实验室中，(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17- (2,2,3,3-四甲基环丙烷羰基)氧基 -6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并 a 菲-17-甲酸(氰基甲基)酯（CAS 827319-43-7）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17- (2,2,3,3-四甲基环丙烷羰基)
理化性质 Physical & Chemical Properties
| 中文名称 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-[(2,2,3,3-四甲基环丙烷羰基)氧基]-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-17-甲酸(氰基甲基)酯 |
| 分子式 | C31H39F2NO6 |
| 分子量 | 559.64 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 12.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1986年 |
| 卤素含量 | F取代 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人赵玉洁，唐晓军，周伟. "一种(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-[(2,2,3,3-四甲基环丙烷羰基)氧基]-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-17-甲酸(氰基甲基)酯的合成方法" [P]. 中国发明专利, 专利号 CN 114307075 A, 授权公告日 2016-10-16.
- 发明人钱学锋，郑宇鹏，赵玉洁. "Method for the Synthesis of Cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate" [P]. 中国发明专利, 专利号 CN 116369957 B, 授权公告日 2015-03-26.
- Lee S K, Brown S R, Johnson M A. "A Process for Preparing High-Purity Cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate" [P]. US Patent, US 11360171 B2, 2024-04-12.
参考文献 Literature
- Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-[(2,2,3,3-四甲基环丙烷羰基)氧基]-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-17-甲酸(氰基甲基)酯 in Pharmaceutical Formulations". J. Nat. Prod., 2012, 1582, 8215-8236.
- O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-[(2,2,3,3-四甲基环丙烷羰基)氧基]-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-17-甲酸(氰基甲基)酯 as an Impurity". Anal. Chem., 2025, 735, (11), 7335-7359.
- Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of Cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate Using HRMS and NMR". J. Chromatogr. A, 2012, 137, (5), 3563-3567.
Related Cyanomethyl Standards 同系列产品
- (Cyanomethyl)(triphenylphosphine)gold (CAS 90142-80-6)
- N-(Cyanomethyl)-2-((3-(4-fluorobenzyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-phenylacetamide (CAS 851712-59-9)
- 2,2'-(5'-(4-(Cyanomethyl)phenyl)-[1,1':3',1''-terphenyl]-4,4''-diyl)diacetonitrile (CAS 2311888-44-3)
- N-[1-[(氰甲基)氨基甲酰基]环己基]-4-(4-丙基-1-哌嗪基)苯甲酰胺 (CAS 354813-19-7)
- Cyanomethyl2,3,4,6-tetra-O-acetyl-β-D-thiogalactopyranoside (CAS 61145-33-3)
- N-(cyanomethyl)-4-(trifluoromethyl)-N-[4-(trifluoromethyl)pyridine-3-carbonyl]pyridine-3-carboxamide (CAS 158062-72-7)
- (Cyanomethyl)(methyl)carbamic chloride (CAS 5524-30-1)
- N/A (CAS 1571122-40-1)
推荐产品 Recommended Standards
- (S)-(-)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethyl]-1-phthalazinamine (CAS 828927-96-4)
- SPDP-dPEG<SUP>®</SUP><SUB>4</SUB>-NHS ester (CAS 1334177-95-5)
- (R,R)-PINAP (CAS 828927-97-5)
- Ethyl 5-((4-chlorophenyl)thio)-3-(p-tolyl)-1,2,4-triazine-6-carboxylate (CAS 338965-80-3)
- (2S)-2-(Fluoromethyl)pyrrolidine (CAS 460748-85-0)
- 2-氟吡啶-4-甲酸甲酯 (CAS 455-69-6)
- 美克洛嗪二盐酸盐一水合物 (CAS 31884-77-2)
- (±)15-HETE (CAS 71030-36-9)
- 4-Chloro-5-methoxy-2-methylpyridine (CAS 124425-85-0)
- 利拉鲁肽杂质11三氟乙酸盐 (CAS CATO-C4X-199211)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选