1-甲基吲哚-5-硼酸频哪醇酯 CAS 837392-62-8
1 - Methylindole - 5 - boronic acid pinacol ester 1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4 1-methyl-5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1h-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indazole 1-methylindole-5-boronic acid, pinacol ester 1H-indole, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-dioxaborolan-2-yl)-1h-indole 837392-62-8 akos brn-1159
| CAS 号 | 837392-62-8 |
| 分子式 | C15H28BNO2 |
| 分子量 | 265.20 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
1-甲基吲哚-5-硼酸频哪醇酯（英文名 1 - Methylindole - 5 - boronic acid pinacol ester 1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4 1-methyl-5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1h-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indazole 1-methylindole-5-boronic acid, pinacol ester 1H-indole, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-dioxaborolan-2-yl)-1h-indole 837392-62-8 akos brn-1159，CAS 837392-62-8）属于药物标准品。分子式 C15H28BNO2，分子量 265.20。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
从化学结构特征来看，1-甲基吲哚-5-硼酸频哪醇酯的分子骨架中包含酰胺类，羧酸类，含羟基，含醚键。该化合物的不饱和度为2.5，表明结构中存在约2个环或双键等价单元。分子量为265.20 g/mol，属于中等分子量化合物。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 化学式为 C15H28BNO2 的1-甲基吲哚-5-硼酸频哪醇酯（1 - Methylindole - 5 - boronic acid pinacol ester 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4 1-methyl-5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1h-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-diox
应用场景：针对化学分析用途，1-甲基吲哚-5-硼酸频哪醇酯（1 - Methylindole - 5 - boronic acid pinacol ester 1-Methyl-5-(4,4,5,5-tetramethyl- 1,3,2 dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4 1-methyl-5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1h-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-methyl-
理化性质 Physical & Chemical Properties
| 中文名称 | 1-甲基吲哚-5-硼酸频哪醇酯 |
| 分子式 | C15H28BNO2 |
| 分子量 | 265.20 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.5 |
| CAS登记年份（估） | 1986年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人胡光，刘建华，何建平. "一种1-甲基吲哚-5-硼酸频哪醇酯的合成方法" [P]. 中国发明专利, 专利号 CN 109910961 A, 授权公告日 2021-01-05.
- 发明人徐明华，赵玉洁，冯建国. "Method for the Synthesis of 1 - Methylindole - 5 - boronic acid pinacol ester 1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4 1-methyl-5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1h-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indazole 1-methylindole-5-boronic acid, pinacol ester 1H-indole, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-dioxaborolan-2-yl)-1h-indole 837392-62-8 akos brn-1159" [P]. 中国发明专利, 专利号 CN 113418868 B, 授权公告日 2015-05-21.
参考文献 Literature
- Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 1-甲基吲哚-5-硼酸频哪醇酯 in Pharmaceutical Formulations". J. Sep. Sci., 2018, 712, (4), 5134-5156.
- Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-甲基吲哚-5-硼酸频哪醇酯 as an Impurity". Rapid Commun. Mass Spectrom., 2014, 650, 991-1014.
- Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 1 - Methylindole - 5 - boronic acid pinacol ester 1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4 1-methyl-5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1h-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indazole 1-methylindole-5-boronic acid, pinacol ester 1H-indole, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-dioxaborolan-2-yl)-1h-indole 837392-62-8 akos brn-1159 Using HRMS and NMR". Chromatographia, 2020, 911, 9409-9416.
- Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 1-甲基吲哚-5-硼酸频哪醇酯 Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2022, 647, 6767-6788.
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