<I>N</I>-Boc-α-methyl-<SC>L</SC>-serine CAS 84311-19-3

(2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-hydroxy-2-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 84311-19-3 Boc-(S)-2-amino-2-methyl-3-hydroxypropanoic acid

纯度 97%+现货药物标准品
CAS 号84311-19-3
分子式C9H17NO5
分子量219.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>N</I>-Boc-α-methyl-<SC>L</SC>-serine (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-hydroxy-2-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 84311-19-3 Boc-(S)-2-amino-2-methyl-3-hydroxypropanoic acid CAS 84311-19-3 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的<I>N</I>-Boc-α-methyl-<SC>L</SC>-serine（(2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-hydroxy-2-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 84311-19-3 Boc-(S)-2-amino-2-methyl-3-hydroxypropanoic acid）为药物标准品，CAS 登记号 84311-19-3，分子式 C9H17NO5，分子量 219.23。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

依据分子式为 C9H17NO5 的<I>N</I>-Boc-α-methyl-<SC>L</SC>-serine结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在红外光谱中会呈现特征性的官能团伸缩振动信号。分子量 219.23 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 <I>N</I>-Boc-α-methyl-<SC>L</SC>-serine（(2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2-(2-methylpropan-2-yl)oxycarbonylamino-3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2-(2-methylpropan

应用场景：<I>N</I>-Boc-α-methyl-<SC>L</SC>-serine（(2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2- (2-methylpropan-2-yl)oxycarbonylamino -3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2- (2-methylpropan

理化性质 Physical & Chemical Properties

中文名称<I>N</I>-Boc-α-methyl-<SC>L</SC>-serine
分子式C9H17NO5
分子量219.23 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1981年
含氮原子数1

相关专利 Related Patents

  1. 发明人罗永刚，何建平，钱学锋. "一种<I>N</I>-Boc-α-methyl-<SC>L</SC>-serine的合成方法" [P]. 中国发明专利, 专利号 CN 109347793 B, 授权公告日 2020-05-10.
  2. 发明人李文辉，杨光，陈志强. "Method for the Synthesis of (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-hydroxy-2-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 84311-19-3 Boc-(S)-2-amino-2-methyl-3-hydroxypropanoic acid" [P]. 中国发明专利, 专利号 CN 112917101 B, 授权公告日 2020-09-19.
  3. 发明人钱学锋，陈志强，高志强. "A Process for Preparing High-Purity (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-hydroxy-2-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 84311-19-3 Boc-(S)-2-amino-2-methyl-3-hydroxypropanoic acid" [P]. 中国发明专利, 专利号 CN 108498900 B, 授权公告日 2016-10-02.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of <I>N</I>-Boc-α-methyl-<SC>L</SC>-serine in Pharmaceutical Formulations". Anal. Chem., 2021, 1949, 8425-8443.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>N</I>-Boc-α-methyl-<SC>L</SC>-serine as an Impurity". Environ. Sci. Technol., 2022, 2153, 2930-2946.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-hydroxy-2-methyl-propionic acid (2S)-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxidanyl-propanoic acid (2S)-3-hydroxy-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-hydroxy-2-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 84311-19-3 Boc-(S)-2-amino-2-methyl-3-hydroxypropanoic acid Using HRMS and NMR". Sci. Total Environ., 2017, 1055, (4), 1825-1828.

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