(<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚 CAS 848821-58-9
(2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine (2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine, 0.05M solution in toluene (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanoltrimethylsilyl ether solution (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine, 0.05M solution in toluene (S)-|A,|A-Diphenylprolinol trimethylsilyl ether (S)-|A,|A-Diphenylprolinol trimethylsilyl ether, 0.05M solution in toluene 848821-58-9
| CAS 号 | 848821-58-9 |
| 分子式 | C20H39NOSi |
| 分子量 | 337.62 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CATO 佳途供应的(<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚（(2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine (2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine, 0.05M solution in toluene (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanoltrimethylsilyl ether solution (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine, 0.05M solution in toluene (S)-|A,|A-Diphenylprolinol trimethylsilyl ether (S)-|A,|A-Diphenylprolinol trimethylsilyl ether, 0.05M solution in toluene 848821-58-9）为药物标准品，CAS 登记号 848821-58-9，分子式 C20H39NOSi，分子量 337.62。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。
(<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚（(2S)-2-Diphenyl(trimethylsilyl)oxymethylpyrrolidine (2S)-2-Diphenyl(trimethylsilyl)oxymethylpyrrolidine, 0.05M solution in toluene (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanoltrimethylsilyl ether solution (S)-2-Diphenyl(trimethylsilanyloxy)methylpyrrolidine (S)-2-Diphenyl(trimethylsilanyloxy)methylpyrrolidine, 0.05M solution in toluene (S)-|A,|A-Diphenylprolinol trimethylsilyl ether
应用场景：从实际应用出发，(<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚（CAS 848821-58-9）在化学分析中作为关键的基准对照物质。 推荐以(<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存
理化性质 Physical & Chemical Properties
| 中文名称 | (<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚 |
| 分子式 | C20H39NOSi |
| 分子量 | 337.62 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1987年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人朱建伟，林芳，王建平. "一种(<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚的合成方法" [P]. 中国发明专利, 专利号 CN 109016081 A, 授权公告日 2021-05-10.
- 发明人周伟，杨光，赵玉洁. "Method for the Synthesis of (2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine (2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine, 0.05M solution in toluene (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanoltrimethylsilyl ether solution (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine, 0.05M solution in toluene (S)-|A,|A-Diphenylprolinol trimethylsilyl ether (S)-|A,|A-Diphenylprolinol trimethylsilyl ether, 0.05M solution in toluene 848821-58-9" [P]. 中国发明专利, 专利号 CN 117620918 A, 授权公告日 2024-12-23.
参考文献 Literature
- Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2014, 2142, 8512-8537.
- Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(–)-α,α-二苯基-2-吡咯烷甲醇三甲基硅基醚 as an Impurity". Anal. Methods, 2013, 2028, 9442-9458.
- Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of (2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine (2S)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine, 0.05M solution in toluene (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanoltrimethylsilyl ether solution (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[Diphenyl(trimethylsilanyloxy)methyl]pyrrolidine, 0.05M solution in toluene (S)-|A,|A-Diphenylprolinol trimethylsilyl ether (S)-|A,|A-Diphenylprolinol trimethylsilyl ether, 0.05M solution in toluene 848821-58-9 Using HRMS and NMR". J. Pharm. Biomed. Anal., 2018, 2434, 2065-2082.
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