(<I>S</I>)-α,α-双 [3,5-双（三氟甲基）苯基]-2-吡咯烷甲醇三甲基硅醚 CAS 848821-61-4

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine (S)-|A,|A-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-|A,|A-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether 848821-61-4

纯度 97%+现货药物标准品
CAS 号848821-61-4
分子式C24H35F12NOSi
分子量609.61 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-α,α-双 [3,5-双（三氟甲基）苯基]-2-吡咯烷甲醇三甲基硅醚 (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine (S)-|A,|A-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-|A,|A-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether 848821-61-4 CAS 848821-61-4 结构式 Chemical Structure

产品介绍 Description

(<I>S</I>)-α,α-双 [3,5-双（三氟甲基）苯基]-2-吡咯烷甲醇三甲基硅醚（(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine (S)-|A,|A-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-|A,|A-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether 848821-61-4）是药物分析与质量控制领域常用的药物标准品，CAS 号 848821-61-4。分子式 C24H35F12NOSi，分子量 609.61。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，(<I>S</I>)-α,α-双 3,5-双（三氟甲基）苯基-2-吡咯烷甲醇三甲基硅醚的分子量为609.61 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 848821-61-4 对应的化合物(<I>S</I>)-α,α-双 3,5-双（三氟甲基）苯基-2-吡咯烷甲醇三甲基硅醚（英文标识 (S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methylpyrrolidine (S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methylpyrrolidine (S)-|A,|A-Bis3,5-bis(trifluoromethyl)phenyl-2-pyrrolidinemethanol trimethylsilyl ether (S)-|A,|A-3,5-Bis(trifluoromethyl)phenylprolinol trimethylsilyl ethe

应用场景：针对化学分析用途，(<I>S</I>)-α,α-双 3,5-双（三氟甲基）苯基 -2-吡咯烷甲醇三甲基硅醚（(S)-2- (Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl pyrrolidine (S)-2- (Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl pyrrolidine (S)-|A,|A-Bis 3,5-bis(trifluoromethyl)phenyl -2-pyrrolidinemethanol trimethylsilyl

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-α,α-双 [3,5-双（三氟甲基）苯基]-2-吡咯烷甲醇三甲基硅醚
分子式C24H35F12NOSi
分子量609.61 g/mol
外观形态白色至类白色无定形粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1987年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. 发明人李文辉，钱学锋，郭海燕. "一种(<I>S</I>)-α,α-双 [3,5-双（三氟甲基）苯基]-2-吡咯烷甲醇三甲基硅醚的合成方法" [P]. 中国发明专利, 专利号 CN 113333741 B, 授权公告日 2024-01-09.
  2. 发明人郭海燕，张德明，胡光. "Method for the Synthesis of (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine (S)-|A,|A-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-|A,|A-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether 848821-61-4" [P]. 中国发明专利, 专利号 CN 112325153 B, 授权公告日 2020-06-25.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-α,α-双 [3,5-双（三氟甲基）苯基]-2-吡咯烷甲醇三甲基硅醚 in Pharmaceutical Formulations". Talanta, 2023, 2101, (3), 7775-7794.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-α,α-双 [3,5-双（三氟甲基）苯基]-2-吡咯烷甲醇三甲基硅醚 as an Impurity". J. Agric. Food Chem., 2025, 2438, (4), 3267-3281.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine (S)-|A,|A-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (S)-|A,|A-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether 848821-61-4 Using HRMS and NMR". J. Sep. Sci., 2012, 663, 4494-4498.

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