3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid CAS 857228-20-7
3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid
| CAS 号 | 857228-20-7 |
| 分子式 | C9H10N4O4 |
| 分子量 | 238.20 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid（3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid，CAS 857228-20-7），分子式 C9H10N4O4，分子量 238.20。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid（3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid），CAS注册编号 857228-20-7，化学分子式为 C9H10N4O4，分子量 238.20 g/mol。 受分子结构中氨基酸衍生物，酰胺类，含羟基，含醚键的影响，3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid表现为类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括238.20 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 本品定
应用场景：3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid（3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid，CAS 857228-20-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据
理化性质 Physical & Chemical Properties
| 中文名称 | 3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid |
| 分子式 | C9H10N4O4 |
| 分子量 | 238.20 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 7.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1987年 |
| 含氮原子数 | 4 |
相关专利 Related Patents
- 发明人郭海燕，韩伟，黄志刚. "一种3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 111278469 A, 授权公告日 2019-07-26.
- Lee S K, Hughes D C, Brown S R. "Method for the Synthesis of 3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid" [P]. US Patent, US 11777697 B2, 2016-08-28.
- 发明人冯建国，杨光，唐晓军. "A Process for Preparing High-Purity 3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid" [P]. 中国发明专利, 专利号 CN 112298159 A, 授权公告日 2019-02-06.
参考文献 Literature
- O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid in Pharmaceutical Formulations". Talanta, 2023, 1442, (3), 9498-9503.
- Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid as an Impurity". J. Sep. Sci., 2013, 303, (12), 1552-1560.
- Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid Using HRMS and NMR". Anal. Chem., 2020, 1496, 5840-5845.
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