1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯 CAS 864754-16-5

1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid pinacol ester 97% 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid, pinacol ester 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester 864754-16-5 [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-acetic acid ethyl ester ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-acetate ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl)acetate ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]acetate

纯度 97%+现货药物标准品
CAS 号864754-16-5
分子式C13H25BN2O4
分子量284.16 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid pinacol ester 97% 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid, pinacol ester 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester 864754-16-5 [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-acetic acid ethyl ester ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-acetate ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl)acetate ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]acetate CAS 864754-16-5 结构式 Chemical Structure

产品介绍 Description

CAS 864754-16-5 对应的1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯（1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid pinacol ester 97% 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid, pinacol ester 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester 864754-16-5 [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-acetic acid ethyl ester ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-acetate ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl)acetate ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]acetate）为 CATO 佳途药物标准品产品线成员。分子式 C13H25BN2O4，分子量 284.16。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯的产生途径与其化学式中酰胺类，羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 864754-16-5 对应的化合物1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯（英文标识 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid pinacol ester 97% 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid, pinacol ester 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester 864754-16-5 4-(4,4,5,5-Tetramethyl-1,3,2dioxaborolan-2-yl)-pyrazol-1-yl-acetic acid ethyl ester ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxabo

应用场景：在化学分析实验室中，1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯（CAS 864754-16-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议

理化性质 Physical & Chemical Properties

中文名称1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯
分子式C13H25BN2O4
分子量284.16 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.5
CAS登记年份（估）1987年
含氮原子数2

相关专利 Related Patents

  1. Björnsson E, Lefèvre J P, Kowalski A. "一种1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯的合成方法" [P]. European Patent, EP 3165457 A1, 2017-05-15.
  2. Schröder R, Stevens L M, Thompson G K. "Method for the Synthesis of 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid pinacol ester 97% 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid, pinacol ester 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester 864754-16-5 [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-acetic acid ethyl ester ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-acetate ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl)acetate ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]acetate" [P]. US Patent, US 10417798 B2, 2015-01-06.
  3. 发明人唐晓军，郭海燕，孙丽萍. "A Process for Preparing High-Purity 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid pinacol ester 97% 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid, pinacol ester 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester 864754-16-5 [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-acetic acid ethyl ester ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-acetate ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl)acetate ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]acetate" [P]. 中国发明专利, 专利号 CN 115803568 A, 授权公告日 2025-05-03.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯 in Pharmaceutical Formulations". Chemosphere, 2015, 861, 6247-6270.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(乙氧基羰基甲基)-1<I>H</I>-吡唑-4-硼酸频哪醇酯 as an Impurity". Anal. Methods, 2018, 286, 1967-1991.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid pinacol ester 97% 1-(ethoxycarbonylmethyl)-1h-pyrazole-4-boronic acid, pinacol ester 1-(ethoxycarbonylmethyl)pyrazole-4-boronic acid pinacol ester 864754-16-5 [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-acetic acid ethyl ester ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-acetate ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl)acetate ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]acetate Using HRMS and NMR". Food Chem., 2016, 1904, (7), 9480-9493.

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