3,5-双三氟甲基苯乙炔 CAS 88444-81-9

1-ethynyl-3,5-bis(trifluoromethyl)benze& 1-ethynyl-3,5-bis(trifluoromethyl)benzene 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoic acid 3&#39,5&#39-bis(trifluoromethyl)phenyl acetylene 3',5'-Bis(trifluoromethyl)phenyl acetylene 3',5'-bis-trifluoromethylphenyl acetylene 3,5-bis(trifluoromethyl)-1-ethynylbenzene 3,5-bis(trifluoromethyl)phenylacetylene 3,5-bis(trifluoromethyl)phenylacetylene 99+% 88444-81-9 salor-int l308668-1ea

纯度 97%+现货药物标准品
CAS 号88444-81-9
分子式C10H10F6
分子量244.18 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3,5-双三氟甲基苯乙炔 1-ethynyl-3,5-bis(trifluoromethyl)benze& 1-ethynyl-3,5-bis(trifluoromethyl)benzene 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoic acid 3&#39,5&#39-bis(trifluoromethyl)phenyl acetylene 3',5'-Bis(trifluoromethyl)phenyl acetylene 3',5'-bis-trifluoromethylphenyl acetylene 3,5-bis(trifluoromethyl)-1-ethynylbenzene 3,5-bis(trifluoromethyl)phenylacetylene 3,5-bis(trifluoromethyl)phenylacetylene 99+% 88444-81-9 salor-int l308668-1ea CAS 88444-81-9 结构式 Chemical Structure

产品介绍 Description

3,5-双三氟甲基苯乙炔（1-ethynyl-3,5-bis(trifluoromethyl)benze& 1-ethynyl-3,5-bis(trifluoromethyl)benzene 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoic acid 3&#39,5&#39-bis(trifluoromethyl)phenyl acetylene 3',5'-Bis(trifluoromethyl)phenyl acetylene 3',5'-bis-trifluoromethylphenyl acetylene 3,5-bis(trifluoromethyl)-1-ethynylbenzene 3,5-bis(trifluoromethyl)phenylacetylene 3,5-bis(trifluoromethyl)phenylacetylene 99+% 88444-81-9 salor-int l308668-1ea）是药物分析与质量控制领域常用的药物标准品，CAS 号 88444-81-9。分子式 C10H10F6，分子量 244.18。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 3,5-双三氟甲基苯乙炔（1-ethynyl-3,5-bis(trifluoromethyl)benze& 1-ethynyl-3,5-bis(trifluoromethyl)benzene 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopentabbenzofuran-5-butanoic acid 3&39,5&39-bis(trifluoromethyl)phenyl acetylene 3',5'-Bis(trifluoromethyl)phenyl acetylene 3',5'-bis-trifluoromethylphenyl acetylene 3,5-bis(trifluoromethyl)-1-ethynylbenzene 3,5-bis(trifluoromethyl)phenylacetyl

应用场景：针对化学分析用途，3,5-双三氟甲基苯乙炔（1-ethynyl-3,5-bis(trifluoromethyl)benze& 1-ethynyl-3,5-bis(trifluoromethyl)benzene 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta b benzofuran-5-butanoic acid 3& 39,5& 39-bis(trifluoromethyl)phenyl acetylene 3',5'-Bis(trifluoromethyl)phenyl a

理化性质 Physical & Chemical Properties

中文名称3,5-双三氟甲基苯乙炔
分子式C10H10F6
分子量244.18 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1982年
卤素含量F取代

相关专利 Related Patents

  1. 发明人胡光，赵玉洁，何建平. "一种3,5-双三氟甲基苯乙炔的合成方法" [P]. 中国发明专利, 专利号 CN 116579211 B, 授权公告日 2020-08-10.
  2. 发明人郑宇鹏，沈红梅，孙丽萍. "Method for the Synthesis of 1-ethynyl-3,5-bis(trifluoromethyl)benze& 1-ethynyl-3,5-bis(trifluoromethyl)benzene 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoic acid 3&#39,5&#39-bis(trifluoromethyl)phenyl acetylene 3',5'-Bis(trifluoromethyl)phenyl acetylene 3',5'-bis-trifluoromethylphenyl acetylene 3,5-bis(trifluoromethyl)-1-ethynylbenzene 3,5-bis(trifluoromethyl)phenylacetylene 3,5-bis(trifluoromethyl)phenylacetylene 99+% 88444-81-9 salor-int l308668-1ea" [P]. 中国发明专利, 专利号 CN 113054991 B, 授权公告日 2024-09-09.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 3,5-双三氟甲基苯乙炔 in Pharmaceutical Formulations". Anal. Methods, 2011, 2061, 1914-1942.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3,5-双三氟甲基苯乙炔 as an Impurity". J. Sep. Sci., 2025, 2239, (3), 9134-9141.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 1-ethynyl-3,5-bis(trifluoromethyl)benze& 1-ethynyl-3,5-bis(trifluoromethyl)benzene 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoic acid 3&#39,5&#39-bis(trifluoromethyl)phenyl acetylene 3',5'-Bis(trifluoromethyl)phenyl acetylene 3',5'-bis-trifluoromethylphenyl acetylene 3,5-bis(trifluoromethyl)-1-ethynylbenzene 3,5-bis(trifluoromethyl)phenylacetylene 3,5-bis(trifluoromethyl)phenylacetylene 99+% 88444-81-9 salor-int l308668-1ea Using HRMS and NMR". Anal. Chim. Acta, 2012, 2247, (4), 5353-5363.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 3,5-双三氟甲基苯乙炔 Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2023, 1957, 3861-3875.

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