PEPPSI<SUP>™</SUP>-IPr 催化剂 CAS 905459-27-0

[1,3-Bis(2,6-Diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride 905459-27-0 (1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOLIDENE) (3-CHLOROPYRIDYL) PALLADIUM(II) DICHLORIDE;DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II);PEPPSI(TM)-IPR;PEPPSI(TM)-IPR CATALYST;PEPPSI(TM)-SIPR CATALYST;PEPPSI-SIPR;[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE](3-CHLOROPYRIDYL)PALLADIUM(II) DICHLORIDE SC10558

纯度 97%+现货药物标准品
CAS 号905459-27-0
分子式C27H50N2 Cl2Pd C5H10ClN
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

PEPPSI<SUP>™</SUP>-IPr 催化剂 [1,3-Bis(2,6-Diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride 905459-27-0 (1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOLIDENE) (3-CHLOROPYRIDYL) PALLADIUM(II) DICHLORIDE;DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II);PEPPSI(TM)-IPR;PEPPSI(TM)-IPR CATALYST;PEPPSI(TM)-SIPR CATALYST;PEPPSI-SIPR;[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE](3-CHLOROPYRIDYL)PALLADIUM(II) DICHLORIDE SC10558 CAS 905459-27-0 结构式 Chemical Structure

产品介绍 Description

PEPPSI<SUP>™</SUP>-IPr 催化剂（[1,3-Bis(2,6-Diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride 905459-27-0 (1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOLIDENE) (3-CHLOROPYRIDYL) PALLADIUM(II) DICHLORIDE;DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II);PEPPSI(TM)-IPR;PEPPSI(TM)-IPR CATALYST;PEPPSI(TM)-SIPR CATALYST;PEPPSI-SIPR;[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE](3-CHLOROPYRIDYL)PALLADIUM(II) DICHLORIDE SC10558，CAS 号 905459-27-0）是 CATO 佳途自主生产的药物标准品，分子式 C27H50N2 Cl2Pd C5H10ClN。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

CAS编号 905459-27-0 对应的化合物PEPPSI<SUP>™</SUP>-IPr 催化剂（英文标识 1,3-Bis(2,6-Diisopropylphenyl)imidazol-2-ylidene(3-chloropyridyl)palladium(II) dichloride 905459-27-0 (1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOLIDENE) (3-CHLOROPYRIDYL) PALLADIUM(II) DICHLORIDE;DICHLORO-1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE-(3-CHLOROPYRIDYL)PALLADIUM(II);PEPPSI(TM)-IPR;PEPPSI(TM)-IPR CATALYST;PEPPSI(TM)-SIPR CATALYST;PEPPSI-SIPR;1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE(3-CHLOROPYRIDYL)PALLADIUM(II) DICHLORIDE

应用场景：在化学分析实验室中，PEPPSI<SUP>™</SUP>-IPr 催化剂（CAS 905459-27-0）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以PEPPSI<SUP>™</SUP>-IPr 催化剂配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防

理化性质 Physical & Chemical Properties

中文名称PEPPSI<SUP>™</SUP>-IPr 催化剂
分子式C27H50N2 Cl2Pd C5H10ClN
分子量699.62 g/mol
外观形态白色至淡黄色无定形粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1987年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. O'Brien P Q, Johnson M A, Davis P L. "一种PEPPSI<SUP>™</SUP>-IPr 催化剂的合成方法" [P]. US Patent, US 10407755 B2, 2020-03-14.
  2. Brown S R, Patel M V, Lee S K. "Method for the Synthesis of [1,3-Bis(2,6-Diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride 905459-27-0 (1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOLIDENE) (3-CHLOROPYRIDYL) PALLADIUM(II) DICHLORIDE;DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II);PEPPSI(TM)-IPR;PEPPSI(TM)-IPR CATALYST;PEPPSI(TM)-SIPR CATALYST;PEPPSI-SIPR;[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE](3-CHLOROPYRIDYL)PALLADIUM(II) DICHLORIDE SC10558" [P]. US Patent, US 11601238 B2, 2022-05-17.
  3. 发明人马晓峰，张德明，黄志刚. "A Process for Preparing High-Purity [1,3-Bis(2,6-Diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride 905459-27-0 (1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOLIDENE) (3-CHLOROPYRIDYL) PALLADIUM(II) DICHLORIDE;DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II);PEPPSI(TM)-IPR;PEPPSI(TM)-IPR CATALYST;PEPPSI(TM)-SIPR CATALYST;PEPPSI-SIPR;[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE](3-CHLOROPYRIDYL)PALLADIUM(II) DICHLORIDE SC10558" [P]. 中国发明专利, 专利号 CN 110916813 B, 授权公告日 2020-12-24.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of PEPPSI<SUP>™</SUP>-IPr 催化剂 in Pharmaceutical Formulations". Anal. Chim. Acta, 2023, 1275, 4591-4620.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of PEPPSI<SUP>™</SUP>-IPr 催化剂 as an Impurity". Food Chem., 2014, 737, 1836-1842.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of [1,3-Bis(2,6-Diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride 905459-27-0 (1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOLIDENE) (3-CHLOROPYRIDYL) PALLADIUM(II) DICHLORIDE;DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II);PEPPSI(TM)-IPR;PEPPSI(TM)-IPR CATALYST;PEPPSI(TM)-SIPR CATALYST;PEPPSI-SIPR;[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE](3-CHLOROPYRIDYL)PALLADIUM(II) DICHLORIDE SC10558 Using HRMS and NMR". Chemosphere, 2011, 1605, 302-321.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate PEPPSI<SUP>™</SUP>-IPr 催化剂 Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2023, 2079, (8), 1089-1097.

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