CAS 90996-54-6

4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, (1S,3S,5R,8S,10S,11R,13R,16S,17R)- 90996-54-6 NSC332598 Rhizoxin hydroxy-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyloxazol-4-yl)octa-3,5,7-trienyl]-dimethyl-[?]dione

纯度 97%+现货药物标准品
CAS 号90996-54-6
分子式C35H47NO9
分子量625.75 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, (1S,3S,5R,8S,10S,11R,13R,16S,17R)- 90996-54-6 NSC332598 Rhizoxin hydroxy-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyloxazol-4-yl)octa-3,5,7-trienyl]-dimethyl-[?]dione CAS 90996-54-6 结构式 Chemical Structure

产品介绍 Description

CAS 90996-54-6 对应的（4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, (1S,3S,5R,8S,10S,11R,13R,16S,17R)- 90996-54-6 NSC332598 Rhizoxin hydroxy-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyloxazol-4-yl)octa-3,5,7-trienyl]-dimethyl-[?]dione）为 CATO 佳途药物标准品产品线成员。分子式 C35H47NO9，分子量 625.75。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键的影响，表现为淡黄色至黄色无定形粉末。其固体形态的物理化学属性——包括625.75 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 （4,7,12,18-Tetraoxatetracyclo15.3.1.03,5.011,13heneicos-14-ene-6,19-dione, 10-hydroxy-8-(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl-11,16-dimethyl-, (1S,3S,5R,8S,10S,11R,13R,16S,17R)- 90996-54-6 NSC332598 Rhizoxin hydroxy-(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyloxazol-4-yl)octa-3,5,7-trienyl-dim

应用场景：在化学分析实验室中，（CAS 90996-54-6）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于室温保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C35H47NO9
分子量625.75 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）13.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1982年
含氮原子数1

相关专利 Related Patents

  1. 发明人陈志强，朱建伟，刘建华. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 113289411 B, 授权公告日 2024-10-07.
  2. Thompson G K, Patel M V, Park J H. "Method for the Synthesis of 4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, (1S,3S,5R,8S,10S,11R,13R,16S,17R)- 90996-54-6 NSC332598 Rhizoxin hydroxy-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyloxazol-4-yl)octa-3,5,7-trienyl]-dimethyl-[?]dione" [P]. US Patent, US 11554096 B2, 2015-11-25.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Environ. Sci. Technol., 2021, 1615, (4), 835-858.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Food Chem., 2018, 1526, (1), 4876-4880.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, (1S,3S,5R,8S,10S,11R,13R,16S,17R)- 90996-54-6 NSC332598 Rhizoxin hydroxy-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyloxazol-4-yl)octa-3,5,7-trienyl]-dimethyl-[?]dione Using HRMS and NMR". Talanta, 2022, 2261, (11), 1041-1062.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2022, 1704, (6), 1988-2001.

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