5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid CAS 917089-50-0

5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid

纯度 97%+现货药物标准品
CAS 号917089-50-0
分子式C14H17N3O3S
分子量307.37 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid 5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid CAS 917089-50-0 结构式 Chemical Structure

产品介绍 Description

5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid（5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 917089-50-0。分子式 C14H17N3O3S，分子量 307.37。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C14H17N3O3S 的5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno2,3-dpyrimidine-6-carboxylic acid（5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno2,3-dpyrimidine-6-carboxylic acid），其CAS登记号是 917089-50-0，分子量为 307.37 g/mol。 依据分子式为 C14H17N3O3S 的5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno2,3-dpyrimidi

应用场景：5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno 2,3-d pyrimidine-6-carboxylic acid（5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno 2,3-d pyrimidine-6-carboxylic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno 2,3-d pyrimidine-6-carbox

理化性质 Physical & Chemical Properties

中文名称5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid
分子式C14H17N3O3S
分子量307.37 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. 发明人何建平，罗永刚，李文辉. "一种5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 116522982 B, 授权公告日 2020-03-04.
  2. Mueller T C, Martínez F, Johansson L. "Method for the Synthesis of 5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid" [P]. European Patent, EP 3438981 A1, 2018-09-05.
  3. 发明人黄志刚，郑宇鹏，刘建华. "A Process for Preparing High-Purity 5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid" [P]. 中国发明专利, 专利号 CN 113177706 A, 授权公告日 2025-11-18.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid in Pharmaceutical Formulations". J. Chromatogr. A, 2011, 1976, (1), 7456-7474.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid as an Impurity". Chemosphere, 2024, 1768, 3463-3488.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid Using HRMS and NMR". Talanta, 2015, 1994, (10), 2188-2213.

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