5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione CAS 92259-24-0

5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione

纯度 97%+现货药物标准品
CAS 号92259-24-0
分子式C8H10N2O5S
分子量246.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione CAS 92259-24-0 结构式 Chemical Structure

产品介绍 Description

CAS 92259-24-0 对应的5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione（5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione）为 CATO 佳途药物标准品产品线成员。分子式 C8H10N2O5S，分子量 246.24。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione在内的目标物的控制。 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione（5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione），CAS注册编号 92259-24-0，化学分子式为 C8H10N2O5S，分子量 246.24 g/mol。 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione（C8H10N2O5S）含有含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合L

应用场景：5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione（5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione，CAS 92259-24-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏

理化性质 Physical & Chemical Properties

中文名称5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
分子式C8H10N2O5S
分子量246.24 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1983年
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. Björnsson E, Mueller T C, Sørensen M. "一种5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione的合成方法" [P]. European Patent, EP 3933612 A1, 2021-01-21.
  2. 发明人沈红梅，林芳，徐明华. "Method for the Synthesis of 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione" [P]. 中国发明专利, 专利号 CN 115978731 B, 授权公告日 2017-06-11.
  3. Mueller T, Thompson G K, Brown S R. "A Process for Preparing High-Purity 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione" [P]. US Patent, US 10322676 B2, 2022-02-03.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2010, 126, (2), 8455-8480.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione as an Impurity". J. Pharm. Biomed. Anal., 2012, 1553, 4404-4416.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Using HRMS and NMR". Anal. Chem., 2020, 1379, (7), 5401-5412.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 5-(1,1-dioxidotetrahydrothien-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2010, 1903, (12), 1093-1117.

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