[3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 937605-80-6

[3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid

纯度 97%+现货药物标准品
CAS 号937605-80-6
分子式C16H12F3N3O2
分子量335.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid [3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 937605-80-6 结构式 Chemical Structure

产品介绍 Description

[3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid（[3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 937605-80-6。分子式 C16H12F3N3O2，分子量 335.28。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo3,4-bpyridin-1-ylacetic acid的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 937605-80-6 对应的化合物3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo3,4-bpyridin-1-ylacetic acid（英文标识 3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo3,4-bpyridin-1-ylacetic acid），化学式 C16H12F3N3O2，相对分子质量 335.28。 3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo3,4-bpyridin-1-ylacetic acid（分子式 C16H12F3N3O2）的化学结构中包含含氮杂环结构，酰胺类，含羟基

应用场景： 3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid（ 3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid，CAS 937605-80-6）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以 3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid配制标准系列工作溶液

理化性质 Physical & Chemical Properties

中文名称[3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
分子式C16H12F3N3O2
分子量335.28 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. Schröder R, Johnson M A, Thompson G K. "一种[3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid的合成方法" [P]. US Patent, US 10784674 B2, 2024-12-13.
  2. 发明人韩伟，朱建伟，孙丽萍. "Method for the Synthesis of [3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 112875869 B, 授权公告日 2020-02-27.
  3. 发明人黄志刚，徐明华，张德明. "A Process for Preparing High-Purity [3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 114115721 B, 授权公告日 2018-12-05.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of [3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid in Pharmaceutical Formulations". Biomed. Chromatogr., 2023, 2412, (6), 666-689.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of [3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid as an Impurity". Environ. Sci. Technol., 2021, 1606, (1), 2132-2138.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of [3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid Using HRMS and NMR". Chromatographia, 2019, 1093, (2), 4971-4996.

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