(<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl CAS 944451-24-5

Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl 944451-24-5 (S)-RUCL[(P-CYMENE)(DM-BINAP)]CL;CHLORO[(R)-(+)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;CHLORO[(S)-(-)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;[RUCL(P-CYMENE)((R)-XYLBINAP)]CL;[RUCL(P-CYMENE)((S)-XYLBINAP)]CL;(R)-RUCL[(P-CYMENE)(DM-BINAP)]CL;Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl SC10125

纯度 97%+现货药物标准品
CAS 号944451-24-5
分子式C52H92P2 ClRu C10H14 Cl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl 944451-24-5 (S)-RUCL[(P-CYMENE)(DM-BINAP)]CL;CHLORO[(R)-(+)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;CHLORO[(S)-(-)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;[RUCL(P-CYMENE)((R)-XYLBINAP)]CL;[RUCL(P-CYMENE)((S)-XYLBINAP)]CL;(R)-RUCL[(P-CYMENE)(DM-BINAP)]CL;Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl SC10125 CAS 944451-24-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl（Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl 944451-24-5 (S)-RUCL[(P-CYMENE)(DM-BINAP)]CL;CHLORO[(R)-(+)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;CHLORO[(S)-(-)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;[RUCL(P-CYMENE)((R)-XYLBINAP)]CL;[RUCL(P-CYMENE)((S)-XYLBINAP)]CL;(R)-RUCL[(P-CYMENE)(DM-BINAP)]CL;Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl SC10125，CAS 944451-24-5），分子式 C52H92P2 ClRu C10H14 Cl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

(<I>R</I>)-RuCl(<I>p</I>-cymene)(DM-BINAP)Cl的产生途径与其化学式中有机磷，含氯取代，多环芳烃密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 944451-24-5 对应的化合物(<I>R</I>)-RuCl(<I>p</I>-cymene)(DM-BINAP)Cl（英文标识 Chloro{(R)-(+)-2,2'-bisdi(3,5-xylyl)phosphino-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, RuCl(p-cymene)((R)-xylbinap)Cl 944451-24-5 (S)-RUCL(P-CYMENE)(DM-BINAP)CL;CHLORO(R)-(+)-2,2'-BISDI(3,5-XYLYL)PHOSPHINO-1,1'-BINAPHTHYL(P-CYMENE)RUTHENIUM(II) CHLORIDE;CHLORO(S)-(-)-2,2'-BISDI(3,5-XYLYL)PHOSPHI

应用场景：(<I>R</I>)-RuCl (<I>p</I>-cymene)(DM-BINAP) Cl（Chloro{(R)-(+)-2,2'-bis di(3,5-xylyl)phosphino -1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, RuCl(p-cymene)((R)-xylbinap) Cl 944451-24-5 (S)-RUCL (P-CYMENE)(DM-BINAP) CL;CHLORO (R)-(+)-2,2'-BIS DI(3,5-XYLYL)PHOSPHINO -1,1'-BINAPHTHYL (P-CYMENE)RUT

理化性质 Physical & Chemical Properties

中文名称(<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl
分子式C52H92P2 ClRu C10H14 Cl
分子量1085.45 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
卤素含量Cl取代

相关专利 Related Patents

  1. 发明人孙丽萍，刘建华，韩伟. "一种(<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl的合成方法" [P]. 中国发明专利, 专利号 CN 110869247 B, 授权公告日 2016-04-10.
  2. 发明人朱建伟，杨光，李文辉. "Method for the Synthesis of Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl 944451-24-5 (S)-RUCL[(P-CYMENE)(DM-BINAP)]CL;CHLORO[(R)-(+)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;CHLORO[(S)-(-)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;[RUCL(P-CYMENE)((R)-XYLBINAP)]CL;[RUCL(P-CYMENE)((S)-XYLBINAP)]CL;(R)-RUCL[(P-CYMENE)(DM-BINAP)]CL;Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl SC10125" [P]. 中国发明专利, 专利号 CN 110385699 A, 授权公告日 2016-11-11.
  3. 发明人罗永刚，韩伟，黄志刚. "A Process for Preparing High-Purity Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl 944451-24-5 (S)-RUCL[(P-CYMENE)(DM-BINAP)]CL;CHLORO[(R)-(+)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;CHLORO[(S)-(-)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;[RUCL(P-CYMENE)((R)-XYLBINAP)]CL;[RUCL(P-CYMENE)((S)-XYLBINAP)]CL;(R)-RUCL[(P-CYMENE)(DM-BINAP)]CL;Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl SC10125" [P]. 中国发明专利, 专利号 CN 116552505 A, 授权公告日 2015-01-08.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl in Pharmaceutical Formulations". J. Chromatogr. A, 2024, 1023, 4925-4928.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl as an Impurity". Chromatographia, 2015, 2410, (7), 881-898.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl 944451-24-5 (S)-RUCL[(P-CYMENE)(DM-BINAP)]CL;CHLORO[(R)-(+)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;CHLORO[(S)-(-)-2,2'-BIS[DI(3,5-XYLYL)PHOSPHINO]-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM(II) CHLORIDE;[RUCL(P-CYMENE)((R)-XYLBINAP)]CL;[RUCL(P-CYMENE)((S)-XYLBINAP)]CL;(R)-RUCL[(P-CYMENE)(DM-BINAP)]CL;Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride, [RuCl(p-cymene)((R)-xylbinap)]Cl SC10125 Using HRMS and NMR". Molecules, 2010, 2269, 7147-7156.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate (<I>R</I>)-RuCl[(<I>p</I>-cymene)(DM-BINAP)]Cl Profile in Drug Substances According to ICH Guidelines". Talanta, 2019, 464, 2386-2389.

Related Chloro Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...