18:1 Monomethyl PE CAS 96687-23-9

(9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine 96687-23-9 CHEBI:85962 MMPE(18:1(9Z)/18:1(9Z)) N-Methyl-1,2-dioleoylphosphatidylethanolamine PE-NMe(18:1(9Z)/18:1(9Z)) PE-NMe(18:1/18:1)

纯度 97%+现货药物标准品
CAS 号96687-23-9
分子式C42H80NO8P
分子量758.06 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

18:1 Monomethyl PE (9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine 96687-23-9 CHEBI:85962 MMPE(18:1(9Z)/18:1(9Z)) N-Methyl-1,2-dioleoylphosphatidylethanolamine PE-NMe(18:1(9Z)/18:1(9Z)) PE-NMe(18:1/18:1) CAS 96687-23-9 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的18:1 Monomethyl PE（(9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine 96687-23-9 CHEBI:85962 MMPE(18:1(9Z)/18:1(9Z)) N-Methyl-1,2-dioleoylphosphatidylethanolamine PE-NMe(18:1(9Z)/18:1(9Z)) PE-NMe(18:1/18:1)）为药物标准品，CAS 登记号 96687-23-9，分子式 C42H80NO8P，分子量 758.06。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

受分子结构中酰胺类，含磷酸酯基，羧酸类，含羟基，含醚键的影响，18:1 Monomethyl PE表现为白色至淡黄色无定形粉末。其固体形态的物理化学属性——包括758.06 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 CAS编号 96687-23-9 对应的化合物18:1 Monomethyl PE（英文标识 (9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine

应用场景：18:1 Monomethyl PE（(9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methyletha

理化性质 Physical & Chemical Properties

中文名称18:1 Monomethyl PE
分子式C42H80NO8P
分子量758.06 g/mol
外观形态白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.5
UV特征有紫外吸收
CAS登记年份（估）1984年
含氮原子数1

相关专利 Related Patents

  1. 发明人王建平，林芳，赵玉洁. "一种18:1 Monomethyl PE的合成方法" [P]. 中国发明专利, 专利号 CN 114273897 B, 授权公告日 2019-05-02.
  2. 发明人韩伟，孙丽萍，李文辉. "Method for the Synthesis of (9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine 96687-23-9 CHEBI:85962 MMPE(18:1(9Z)/18:1(9Z)) N-Methyl-1,2-dioleoylphosphatidylethanolamine PE-NMe(18:1(9Z)/18:1(9Z)) PE-NMe(18:1/18:1)" [P]. 中国发明专利, 专利号 CN 108877601 B, 授权公告日 2016-04-19.
  3. Lee S K, Anderson J P, Stevens L M. "A Process for Preparing High-Purity (9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine 96687-23-9 CHEBI:85962 MMPE(18:1(9Z)/18:1(9Z)) N-Methyl-1,2-dioleoylphosphatidylethanolamine PE-NMe(18:1(9Z)/18:1(9Z)) PE-NMe(18:1/18:1)" [P]. US Patent, US 9185089 B2, 2019-12-12.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 18:1 Monomethyl PE in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2014, 149, (9), 1722-1739.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 18:1 Monomethyl PE as an Impurity". Talanta, 2019, 1693, (8), 4989-5019.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of (9R,20Z)-6-hydroxy-6,12-dioxo-5,7,11-trioxa-2-aza-6lambda(5)-phosphanonacos-20-en-9-yl (9Z)-octadec-9-enoate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-monomethyl 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine 1,2-dioleoyl-sn-glycero-3-phospho-N-methylethanolamine 96687-23-9 CHEBI:85962 MMPE(18:1(9Z)/18:1(9Z)) N-Methyl-1,2-dioleoylphosphatidylethanolamine PE-NMe(18:1(9Z)/18:1(9Z)) PE-NMe(18:1/18:1) Using HRMS and NMR". J. Sep. Sci., 2025, 1020, (6), 4004-4009.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 18:1 Monomethyl PE Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2024, 2269, (4), 2157-2163.

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