间苯二甲酰氯 CAS 99-63-8
6A3LDJ6CL3 99-63-8 1,3-Benzenedicarbonyl chloride Isophthaloyl dichloride 1,3-Benzenedicarbonyl dichloride Isophthaloyl chloride 4-09-00-03295 (Beilstein Handbook Reference) m-Benzenedicarbonyl chloride 1,3-Benzenedicarboxylic acid, dichloride BRN 0638342 Dichlorid kyseliny isoftalove [Czech] EINECS 202-774-7 HSDB 5326 Isophthalic acid chloride Isophthalic acid dichloride Isophthalic chloride Isophthalyl chloride Isophthalyl dichloride Isothaloyl chloride NSC 41884 m-Phthalic dichloride m-Phthaloyl chloride meta-Phthalyl dichloride m-Phthalyl dichloride Dichlorid kyseliny isoftalove UNII-6A3LDJ6CL3 EC 202-774-7
| CAS 号 | 99-63-8 |
| 分子式 | C8H10Cl2O2 |
| 分子量 | 209.07 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品间苯二甲酰氯（6A3LDJ6CL3 99-63-8 1,3-Benzenedicarbonyl chloride Isophthaloyl dichloride 1,3-Benzenedicarbonyl dichloride Isophthaloyl chloride 4-09-00-03295 (Beilstein Handbook Reference) m-Benzenedicarbonyl chloride 1,3-Benzenedicarboxylic acid, dichloride BRN 0638342 Dichlorid kyseliny isoftalove [Czech] EINECS 202-774-7 HSDB 5326 Isophthalic acid chloride Isophthalic acid dichloride Isophthalic chloride Isophthalyl chloride Isophthalyl dichloride Isothaloyl chloride NSC 41884 m-Phthalic dichloride m-Phthaloyl chloride meta-Phthalyl dichloride m-Phthalyl dichloride Dichlorid kyseliny isoftalove UNII-6A3LDJ6CL3 EC 202-774-7，CAS 99-63-8），分子式 C8H10Cl2O2，分子量 209.07。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
CAS编号 99-63-8 对应的化合物间苯二甲酰氯（英文标识 6A3LDJ6CL3 99-63-8 1,3-Benzenedicarbonyl chloride Isophthaloyl dichloride 1,3-Benzenedicarbonyl dichloride Isophthaloyl chloride 4-09-00-03295 (Beilstein Handbook Reference) m-Benzenedicarbonyl chloride 1,3-Benzenedicarboxylic acid, dichloride BRN 0638342 Dichlorid kyseliny isoftalove Czech EINECS 202-774-7 HSDB 5326 Isophthalic acid chloride Isophthalic acid dichloride Isophthalic chloride Isophthalyl chloride Isophthalyl dichloride Isothaloyl chloride NSC 4188
应用场景：间苯二甲酰氯（6A3LDJ6CL3 99-63-8 1,3-Benzenedicarbonyl chloride Isophthaloyl dichloride 1,3-Benzenedicarbonyl dichloride Isophthaloyl chloride 4-09-00-03295 (Beilstein Handbook Reference) m-Benzenedicarbonyl chloride 1,3-Benzenedicarboxylic acid, dichloride BRN 0638342 Dichlorid kyseliny isoftalove Czech
理化性质 Physical & Chemical Properties
| 中文名称 | 间苯二甲酰氯 |
| 分子式 | C8H10Cl2O2 |
| 分子量 | 209.07 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1957年 |
| 卤素含量 | Cl取代 |
相关专利 Related Patents
- Mueller T, Klinger H, Park J H. "一种间苯二甲酰氯的合成方法" [P]. US Patent, US 9342864 B2, 2019-09-07.
- 发明人李文辉，沈红梅，胡光. "Method for the Synthesis of 6A3LDJ6CL3 99-63-8 1,3-Benzenedicarbonyl chloride Isophthaloyl dichloride 1,3-Benzenedicarbonyl dichloride Isophthaloyl chloride 4-09-00-03295 (Beilstein Handbook Reference) m-Benzenedicarbonyl chloride 1,3-Benzenedicarboxylic acid, dichloride BRN 0638342 Dichlorid kyseliny isoftalove [Czech] EINECS 202-774-7 HSDB 5326 Isophthalic acid chloride Isophthalic acid dichloride Isophthalic chloride Isophthalyl chloride Isophthalyl dichloride Isothaloyl chloride NSC 41884 m-Phthalic dichloride m-Phthaloyl chloride meta-Phthalyl dichloride m-Phthalyl dichloride Dichlorid kyseliny isoftalove UNII-6A3LDJ6CL3 EC 202-774-7" [P]. 中国发明专利, 专利号 CN 117959221 B, 授权公告日 2016-05-13.
- Stevens L M, Mueller T, Anderson J P. "A Process for Preparing High-Purity 6A3LDJ6CL3 99-63-8 1,3-Benzenedicarbonyl chloride Isophthaloyl dichloride 1,3-Benzenedicarbonyl dichloride Isophthaloyl chloride 4-09-00-03295 (Beilstein Handbook Reference) m-Benzenedicarbonyl chloride 1,3-Benzenedicarboxylic acid, dichloride BRN 0638342 Dichlorid kyseliny isoftalove [Czech] EINECS 202-774-7 HSDB 5326 Isophthalic acid chloride Isophthalic acid dichloride Isophthalic chloride Isophthalyl chloride Isophthalyl dichloride Isothaloyl chloride NSC 41884 m-Phthalic dichloride m-Phthaloyl chloride meta-Phthalyl dichloride m-Phthalyl dichloride Dichlorid kyseliny isoftalove UNII-6A3LDJ6CL3 EC 202-774-7" [P]. US Patent, US 9668357 B2, 2020-07-25.
参考文献 Literature
- Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 间苯二甲酰氯 in Pharmaceutical Formulations". J. Agric. Food Chem., 2013, 2112, (8), 7800-7806.
- Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 间苯二甲酰氯 as an Impurity". Talanta, 2016, 449, (1), 2469-2479.
- Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 6A3LDJ6CL3 99-63-8 1,3-Benzenedicarbonyl chloride Isophthaloyl dichloride 1,3-Benzenedicarbonyl dichloride Isophthaloyl chloride 4-09-00-03295 (Beilstein Handbook Reference) m-Benzenedicarbonyl chloride 1,3-Benzenedicarboxylic acid, dichloride BRN 0638342 Dichlorid kyseliny isoftalove [Czech] EINECS 202-774-7 HSDB 5326 Isophthalic acid chloride Isophthalic acid dichloride Isophthalic chloride Isophthalyl chloride Isophthalyl dichloride Isothaloyl chloride NSC 41884 m-Phthalic dichloride m-Phthaloyl chloride meta-Phthalyl dichloride m-Phthalyl dichloride Dichlorid kyseliny isoftalove UNII-6A3LDJ6CL3 EC 202-774-7 Using HRMS and NMR". J. Chromatogr. A, 2014, 485, (6), 840-855.
- Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 间苯二甲酰氯 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2011, 2079, (4), 8613-8620.
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