6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸 CAS 99199-59-4
6-Fluoro-4-oxo-4H-chromene-2-carboxylic acid 6-fluoro-4-oxo-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid: 6-fluorochromone-2-carboxylic acid 6-fluoro-4-oxo-4h-chromene-2-carboxylic acid 98% 6-fluoro-4-oxo-4h-chromene-2-carboxylicacid98% 6-fluorochromone-2-carboxylic acid 6-fluorochromone-2-carboxylicacid/6-fluoro-4-oxo-4h-chromone-2-carboxylicacid 99199-59-4
| CAS 号 | 99199-59-4 |
| 分子式 | C10H11FO4 |
| 分子量 | 214.19 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 99199-59-4 对应的6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸（6-Fluoro-4-oxo-4H-chromene-2-carboxylic acid 6-fluoro-4-oxo-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid: 6-fluorochromone-2-carboxylic acid 6-fluoro-4-oxo-4h-chromene-2-carboxylic acid 98% 6-fluoro-4-oxo-4h-chromene-2-carboxylicacid98% 6-fluorochromone-2-carboxylic acid 6-fluorochromone-2-carboxylicacid/6-fluoro-4-oxo-4h-chromone-2-carboxylicacid 99199-59-4）为 CATO 佳途药物标准品产品线成员。分子式 C10H11FO4，分子量 214.19。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸的产生途径与其化学式中羧酸类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 99199-59-4 对应的化合物6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸（英文标识 6-Fluoro-4-oxo-4H-chromene-2-carboxylic acid 6-fluoro-4-oxo-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid: 6-fluorochromone-2-carboxylic acid 6-fluoro-4-oxo-4h-chromene-2-carboxylic acid 98% 6-fluoro-4-oxo-4h-chromene-2-carboxylicacid98% 6-fluorochromone-2-carboxylic acid 6-flu
应用场景：在化学分析实验室中，6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸（CAS 99199-59-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应
理化性质 Physical & Chemical Properties
| 中文名称 | 6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸 |
| 分子式 | C10H11FO4 |
| 分子量 | 214.19 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1985年 |
| 卤素含量 | F取代 |
相关专利 Related Patents
- 发明人周伟，郭海燕，冯建国. "一种6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸的合成方法" [P]. 中国发明专利, 专利号 CN 113989047 B, 授权公告日 2019-01-22.
- 发明人何建平，赵玉洁，徐明华. "Method for the Synthesis of 6-Fluoro-4-oxo-4H-chromene-2-carboxylic acid 6-fluoro-4-oxo-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid: 6-fluorochromone-2-carboxylic acid 6-fluoro-4-oxo-4h-chromene-2-carboxylic acid 98% 6-fluoro-4-oxo-4h-chromene-2-carboxylicacid98% 6-fluorochromone-2-carboxylic acid 6-fluorochromone-2-carboxylicacid/6-fluoro-4-oxo-4h-chromone-2-carboxylicacid 99199-59-4" [P]. 中国发明专利, 专利号 CN 116979773 B, 授权公告日 2020-04-24.
参考文献 Literature
- Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸 in Pharmaceutical Formulations". Food Chem., 2018, 1565, (10), 3759-3782.
- Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸 as an Impurity". Biomed. Chromatogr., 2010, 2352, (8), 8386-8398.
- Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 6-Fluoro-4-oxo-4H-chromene-2-carboxylic acid 6-fluoro-4-oxo-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid 6-fluoro-4-oxo-4h-1-benzopyran-2-carboxylic acid: 6-fluorochromone-2-carboxylic acid 6-fluoro-4-oxo-4h-chromene-2-carboxylic acid 98% 6-fluoro-4-oxo-4h-chromene-2-carboxylicacid98% 6-fluorochromone-2-carboxylic acid 6-fluorochromone-2-carboxylicacid/6-fluoro-4-oxo-4h-chromone-2-carboxylicacid 99199-59-4 Using HRMS and NMR". Sci. Total Environ., 2021, 1216, (11), 5555-5566.
- Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 6-氟-4-氧代-4氢-1-苯并吡喃-2-羧酸 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2013, 1316, (3), 1738-1765.
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