methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate CAS 1001519-00-1

methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate

纯度 97%+现货药物标准品
CAS 号1001519-00-1
分子式C11H15N5O2S
分子量281.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate CAS 1001519-00-1 结构式 Chemical Structure

产品介绍 Description

methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate（英文名 methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate，CAS 1001519-00-1）属于药物标准品。分子式 C11H15N5O2S，分子量 281.33。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

作为认证标准物质（CRM），methyl ({4-methyl-5-(3-methyl-1H-pyrazol-1-yl)methyl-4H-1,2,4-triazol-3-yl}thio)acetate满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C11H15N5O2S 的methyl ({4-methyl-5-(3-methyl-1H-pyrazol-1-yl)methyl-4H-1,2,4-triazol-3-yl}thio)acetate（methyl ({4-methyl-5-(3-methyl-1H-pyrazol-1-yl)methyl-4H-1,2,4-triazol-3-yl}thio)acetate），其CAS登记号是 1001519-00-1，分子量为 281.33 g/mol。 methyl ({4-methyl-5-(3-methyl-1H-pyrazol-1-yl)methyl-4H-1,

应用场景：从实际应用出发，methyl ({4-methyl-5- (3-methyl-1H-pyrazol-1-yl)methyl -4H-1,2,4-triazol-3-yl}thio)acetate（CAS 1001519-00-1）在化学分析中作为关键的基准对照物质。 推荐以methyl ({4-methyl-5- (3-methyl-1H-pyrazol-1-yl)methyl -4H-1,2,4-triazol-3-yl}thio)acetate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建

理化性质 Physical & Chemical Properties

中文名称methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate
分子式C11H15N5O2S
分子量281.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数5
含硫原子数1

相关专利 Related Patents

  1. 发明人韩伟，胡光，马晓峰. "一种methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate的合成方法" [P]. 中国发明专利, 专利号 CN 112654726 B, 授权公告日 2021-11-09.
  2. Stevens L M, Chen K W, Williams B T. "Method for the Synthesis of methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate" [P]. US Patent, US 10164531 B2, 2024-08-02.
  3. 发明人刘建华，高志强，杨光. "A Process for Preparing High-Purity methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate" [P]. 中国发明专利, 专利号 CN 111133937 B, 授权公告日 2025-08-24.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate in Pharmaceutical Formulations". Talanta, 2012, 2323, (12), 1359-1383.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate as an Impurity". J. Nat. Prod., 2018, 844, (1), 192-208.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of methyl ({4-methyl-5-[(3-methyl-1H-pyrazol-1-yl)methyl]-4H-1,2,4-triazol-3-yl}thio)acetate Using HRMS and NMR". Chromatographia, 2013, 1062, (3), 2284-2311.

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