3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018127-70-2

3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid

纯度 97%+现货药物标准品
CAS 号1018127-70-2
分子式C15H17F2N3O3
分子量325.31 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid 3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018127-70-2 结构式 Chemical Structure

产品介绍 Description

CAS 1018127-70-2 对应的3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid（3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid）为 CATO 佳途药物标准品产品线成员。分子式 C15H17F2N3O3，分子量 325.31。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，3-2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid的分子量为325.31 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C15H17F2N3O3 的3-2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid（3-2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid），其CAS登记号是 1018127-70-2，分子量为 325.31 g/mol。 从化学结构特征来看，3-2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo3,4-

应用场景：从实际应用出发，3- 2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid（CAS 1018127-70-2）在化学分析中作为关键的基准对照物质。 推荐以3- 2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根

理化性质 Physical & Chemical Properties

中文名称3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
分子式C15H17F2N3O3
分子量325.31 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人林芳，赵玉洁，朱建伟. "一种3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 111497818 A, 授权公告日 2025-06-23.
  2. 发明人罗永刚，沈红梅，黄志刚. "Method for the Synthesis of 3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid" [P]. 中国发明专利, 专利号 CN 117171765 B, 授权公告日 2017-10-19.
  3. 发明人高志强，朱建伟，刘建华. "A Process for Preparing High-Purity 3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid" [P]. 中国发明专利, 专利号 CN 108867683 B, 授权公告日 2022-11-18.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2025, 838, (2), 9538-9556.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid as an Impurity". Molecules, 2021, 2012, (11), 7810-7839.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 3-[2-cyclopentyl-4-(difluoromethyl)-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid Using HRMS and NMR". Chromatographia, 2020, 1691, 4025-4032.

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