N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺) CAS 110874-36-7

N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide)

纯度 97%+现货药物标准品
CAS 号110874-36-7
分子式C34H38N8O12
分子量750.71 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺) N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide) CAS 110874-36-7 结构式 Chemical Structure

产品介绍 Description

CAS 110874-36-7 对应的N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺)（N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide)）为 CATO 佳途药物标准品产品线成员。分子式 C34H38N8O12，分子量 750.71。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺)的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C34H38N8O12 的N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺)（N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide)），其CAS登记号是 110874-36-7，分子量为 750.71 g/mol。 N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2

应用场景：针对化学分析用途，N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺)（N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide)）是具有明确定量溯源的认证级对照品。 推荐以N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-

理化性质 Physical & Chemical Properties

中文名称N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺)
分子式C34H38N8O12
分子量750.71 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）20.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数8

相关专利 Related Patents

  1. 发明人高志强，唐晓军，钱学锋. "一种N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺)的合成方法" [P]. 中国发明专利, 专利号 CN 111264985 B, 授权公告日 2017-05-06.
  2. 发明人郭海燕，林芳，张德明. "Method for the Synthesis of N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide)" [P]. 中国发明专利, 专利号 CN 115468933 B, 授权公告日 2015-02-07.
  3. 发明人朱建伟，唐晓军，黄志刚. "A Process for Preparing High-Purity N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide)" [P]. 中国发明专利, 专利号 CN 117217762 B, 授权公告日 2021-08-23.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺) in Pharmaceutical Formulations". J. Agric. Food Chem., 2020, 621, (11), 8236-8248.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of N,N'-(丁烷-1,4-二基)双(1-羟基-N-(3-(1-羟基-6-氧代-1,6-二氢吡啶-2-甲酰胺基)丙基)-6-氧代-1,6-二氢吡啶-2-甲酰胺) as an Impurity". Rapid Commun. Mass Spectrom., 2017, 1149, (2), 5114-5130.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of N,N'-(Butane-1,4-diyl)bis(1-hydroxy-N-(3-(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamido)propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide) Using HRMS and NMR". Sci. Total Environ., 2017, 911, (2), 3404-3432.

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