1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid CAS 1152536-23-6

1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1152536-23-6
分子式C13H10ClFN2O2
分子量280.68 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid CAS 1152536-23-6 结构式 Chemical Structure

产品介绍 Description

1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid（英文名 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid，CAS 1152536-23-6）属于药物标准品。分子式 C13H10ClFN2O2，分子量 280.68。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid的分子量为280.68 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1152536-23-6 对应的化合物1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid（英文标识 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid），化学式 C13H10ClFN2O2，相对分子质量 280.68。 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid（C13H10ClFN2O2）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代。具有较强的吸湿性，卤素取代增加

应用场景：1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylic acid（1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylic acid，CAS 1152536-23-6）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylic acid配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid
分子式C13H10ClFN2O2
分子量280.68 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人张德明，钱学锋，周伟. "一种1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 114193861 A, 授权公告日 2024-11-16.
  2. 发明人何建平，林芳，刘建华. "Method for the Synthesis of 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 111935177 A, 授权公告日 2022-04-11.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid in Pharmaceutical Formulations". J. Nat. Prod., 2013, 1486, (1), 259-262.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid as an Impurity". Food Chem., 2018, 1597, 9019-9039.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid Using HRMS and NMR". J. Pharm. Biomed. Anal., 2018, 1421, (3), 2503-2526.
  4. Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2015, 2177, 9587-9617.

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