(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone CAS 1171924-53-0

(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone

纯度 97%+现货药物标准品
CAS 号1171924-53-0
分子式C21H25NO3
分子量339.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone (2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone CAS 1171924-53-0 结构式 Chemical Structure

产品介绍 Description

(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone（(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone，CAS 号 1171924-53-0）是 CATO 佳途自主生产的药物标准品，分子式 C21H25NO3，分子量 339.43。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 1171924-53-0 对应的化合物(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-2-(4-hydroxy-phenyl)-ethyl-phenyl}-methanone（英文标识 (2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-2-(4-hydroxy-phenyl)-ethyl-phenyl}-methanone），化学式 C21H25NO3，相对分子质量 339.43。 受分子结构中甾体骨架，酰胺类，含羟基，含醚键的影响，(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-2-(4-hydroxy-phenyl)-ethyl-phenyl}-methanone表现为淡黄色至黄色结晶性粉末。其固体形态的物理化学属性——包括339.43 g/mol的分子量——对于选择合适的样品前处理

应用场景：针对化学分析用途，(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6- 2-(4-hydroxy-phenyl)-ethyl -phenyl}-methanone（(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6- 2-(4-hydroxy-phenyl)-ethyl -phenyl}-methanone）是具有明确定量溯源的认证级对照品。 推荐以(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6- 2-(4-hydroxy-phenyl)-ethyl -phenyl}-methan

理化性质 Physical & Chemical Properties

中文名称(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone
分子式C21H25NO3
分子量339.43 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数1

相关专利 Related Patents

  1. Lee S K, Williams B T, Klinger H. "一种(2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone的合成方法" [P]. US Patent, US 10478775 B2, 2021-08-20.
  2. Mueller T, Johnson M A, Davis P L. "Method for the Synthesis of (2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone" [P]. US Patent, US 9275731 B2, 2022-04-12.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of (2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone in Pharmaceutical Formulations". Chromatographia, 2017, 2097, (1), 2434-2452.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone as an Impurity". Phytochemistry, 2010, 2218, 1067-1072.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of (2,5-Dimethyl-pyrrolidin-1-yl)-{2-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-phenyl}-methanone Using HRMS and NMR". Molecules, 2019, 899, 5517-5520.

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