CAS 1194507-30-6

[6-[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2,4-dioxo-pyrimidin-5-yl]prop-2-enoylamino]hexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate

纯度 97%+现货药物标准品
CAS 号1194507-30-6
分子式C79H127N6O17P
分子量1463.86 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[6-[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2,4-dioxo-pyrimidin-5-yl]prop-2-enoylamino]hexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate CAS 1194507-30-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的（[6-[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2,4-dioxo-pyrimidin-5-yl]prop-2-enoylamino]hexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate）为药物标准品，CAS 登记号 1194507-30-6，分子式 C79H127N6O17P，分子量 1463.86。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

的产生途径与其化学式中含氮杂环结构，酰胺类，含磷酸酯基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 （6-6-3-1-(2R,4S,5R)-5-bis(4-methoxyphenyl)-phenyl-methoxymethyl-4-2-cyanoethoxy-(diisopropylamino)phosphanyloxy-tetrahydrofuran-2-yl-2,4-dioxo-pyrimidin-5-ylprop-2-enoylaminohexylcarbamoyl-6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiroisobenzofuran-1,9'-xanthene-3'-yl 2,2-dimethylpropanoate），CAS注册编号 1194507-30-6，化学分子式为 C79H127N6O17P，分子量 1463.86 g/mol。 （分子式 C79H127N6O17P）的化学结构中包含含氮杂环结构，酰胺类，含磷酸酯基，含羟基，含醚键。在反相色谱体系中

应用场景：（ 6- 6- 3- 1- (2R,4S,5R)-5- bis(4-methoxyphenyl)-phenyl-methoxy methyl -4- 2-cyanoethoxy-(diisopropylamino)phosphanyl oxy-tetrahydrofuran-2-yl -2,4-dioxo-pyrimidin-5-yl prop-2-enoylamino hexylcarbamoyl -6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiro isobenzofuran-1,9'-xanthene -3'-yl 2,2-dimethylpropan

理化性质 Physical & Chemical Properties

中文名称
分子式C79H127N6O17P
分子量1463.86 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）19.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数6

相关专利 Related Patents

  1. 发明人林芳，郭海燕，罗永刚. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111551678 A, 授权公告日 2021-09-13.
  2. Schröder R, Johnson M A, Kumar R. "Method for the Synthesis of [6-[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2,4-dioxo-pyrimidin-5-yl]prop-2-enoylamino]hexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate" [P]. US Patent, US 9565519 B2, 2022-10-02.
  3. 发明人胡光，朱建伟，王建平. "A Process for Preparing High-Purity [6-[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2,4-dioxo-pyrimidin-5-yl]prop-2-enoylamino]hexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate" [P]. 中国发明专利, 专利号 CN 110662238 B, 授权公告日 2019-07-02.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2014, 742, (2), 3697-3715.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Food Chem., 2019, 1583, 3207-3210.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of [6-[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2,4-dioxo-pyrimidin-5-yl]prop-2-enoylamino]hexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate Using HRMS and NMR". Anal. Methods, 2020, 1752, (11), 6945-6969.

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