CAS 128676-84-6

(2-chloro-3-quinolinyl)boronic acid(saltdata: free) (2-chloroquinolin-3-yl)boronic acid 128676-84-6 2 - Chloro - 3 - quinolineboronic acid 2-Chloroquinoline-3-boronic acid 2-chloro-3-quinoline boronic acid 2-chloro-3-quinolyl boronic acid 3-borono-2-chloroquinoline akos brn-0209 boronic acid, (2-chloro-3-quinolinyl)-

纯度 97%+现货药物标准品
CAS 号128676-84-6
分子式C9H7BClNO2
分子量207.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2-chloro-3-quinolinyl)boronic acid(saltdata: free) (2-chloroquinolin-3-yl)boronic acid 128676-84-6 2 - Chloro - 3 - quinolineboronic acid 2-Chloroquinoline-3-boronic acid 2-chloro-3-quinoline boronic acid 2-chloro-3-quinolyl boronic acid 3-borono-2-chloroquinoline akos brn-0209 boronic acid, (2-chloro-3-quinolinyl)- CAS 128676-84-6 结构式 Chemical Structure

产品介绍 Description

CAS 128676-84-6 对应的（(2-chloro-3-quinolinyl)boronic acid(saltdata: free) (2-chloroquinolin-3-yl)boronic acid 128676-84-6 2 - Chloro - 3 - quinolineboronic acid 2-Chloroquinoline-3-boronic acid 2-chloro-3-quinoline boronic acid 2-chloro-3-quinolyl boronic acid 3-borono-2-chloroquinoline akos brn-0209 boronic acid, (2-chloro-3-quinolinyl)-）为 CATO 佳途药物标准品产品线成员。分子式 C9H7BClNO2，分子量 207.42。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

化学式为 C9H7BClNO2 的（(2-chloro-3-quinolinyl)boronic acid(saltdata: free) (2-chloroquinolin-3-yl)boronic acid 128676-84-6 2 - Chloro - 3 - quinolineboronic acid 2-Chloroquinoline-3-boronic acid 2-chloro-3-quinoline boronic acid 2-chloro-3-quinolyl boronic acid 3-borono-2-chloroquinoline akos brn-0209 boronic acid, (2-chloro-3-quinolinyl)-），其CAS登记号是 128676-84-6，分子量为 207.42 g/mol。 依据分子式为 C9H7BClNO2 的结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 207.42 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值

应用场景：（(2-chloro-3-quinolinyl)boronic acid(saltdata: free) (2-chloroquinolin-3-yl)boronic acid 128676-84-6 2 - Chloro - 3 - quinolineboronic acid 2-Chloroquinoline-3-boronic acid 2-chloro-3-quinoline boronic acid 2-chloro-3-quinolyl boronic acid 3-borono-2-chloroquinoline akos brn-0209 boronic acid, (2-ch

理化性质 Physical & Chemical Properties

中文名称
分子式C9H7BClNO2
分子量207.42 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1993年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Björnsson E, Nielsen H, Schröder R. "一种的合成方法" [P]. European Patent, EP 3671453 A1, 2020-03-27.
  2. 发明人杨光，王建平，张德明. "Method for the Synthesis of (2-chloro-3-quinolinyl)boronic acid(saltdata: free) (2-chloroquinolin-3-yl)boronic acid 128676-84-6 2 - Chloro - 3 - quinolineboronic acid 2-Chloroquinoline-3-boronic acid 2-chloro-3-quinoline boronic acid 2-chloro-3-quinolyl boronic acid 3-borono-2-chloroquinoline akos brn-0209 boronic acid, (2-chloro-3-quinolinyl)-" [P]. 中国发明专利, 专利号 CN 108351749 A, 授权公告日 2023-06-20.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chem., 2011, 1244, (4), 5521-5529.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Chemosphere, 2018, 319, (12), 6578-6593.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of (2-chloro-3-quinolinyl)boronic acid(saltdata: free) (2-chloroquinolin-3-yl)boronic acid 128676-84-6 2 - Chloro - 3 - quinolineboronic acid 2-Chloroquinoline-3-boronic acid 2-chloro-3-quinoline boronic acid 2-chloro-3-quinolyl boronic acid 3-borono-2-chloroquinoline akos brn-0209 boronic acid, (2-chloro-3-quinolinyl)- Using HRMS and NMR". Environ. Sci. Technol., 2018, 2454, (3), 5823-5843.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2010, 1082, (8), 6362-6368.

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