2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride CAS 1305712-17-7

2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride

纯度 97%+现货药物标准品
CAS 号1305712-17-7
分子式C11H14ClFN2O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride 2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride CAS 1305712-17-7 结构式 Chemical Structure

产品介绍 Description

CAS 1305712-17-7 对应的2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride（2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C11H14ClFN2O HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

2-{1-(2-chloro-4-fluorophenyl)ethylamino}-N-methylacetamide hydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C11H14ClFN2O HCl 的2-{1-(2-chloro-4-fluorophenyl)ethylamino}-N-methylacetamide hydrochloride（2-{1-(2-chloro-4-fluorophenyl)ethylamino}-N-methylacetamide hydrochloride），其CAS登记号是 1305712-17-7，分子量为 281.15 g/mol。 依据分子式为 C11H14ClFN2O HCl 的2-{1-(2-chloro-4-fluorophenyl)ethylamino}-N-methylacetamide hydrochloride结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取

应用场景：针对化学分析用途，2-{ 1-(2-chloro-4-fluorophenyl)ethyl amino}-N-methylacetamide hydrochloride（2-{ 1-(2-chloro-4-fluorophenyl)ethyl amino}-N-methylacetamide hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以2-{ 1-(2-chloro-4-fluorophenyl)ethyl amino}-N-methylacetamide hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）

理化性质 Physical & Chemical Properties

中文名称2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride
分子式C11H14ClFN2O HCl
分子量281.15 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人张德明，陈志强，沈红梅. "一种2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 108613966 A, 授权公告日 2016-01-24.
  2. Martínez F, Rossi M, Björnsson E. "Method for the Synthesis of 2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride" [P]. European Patent, EP 3820360 A1, 2016-10-12.
  3. Lefèvre J P, Mueller T C, Jørgensen K. "A Process for Preparing High-Purity 2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride" [P]. European Patent, EP 3542980 A1, 2020-11-10.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride in Pharmaceutical Formulations". Talanta, 2011, 2063, (8), 6225-6238.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride as an Impurity". Environ. Sci. Technol., 2012, 1508, (1), 594-602.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride Using HRMS and NMR". Molecules, 2020, 2365, 6555-6562.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 2-{[1-(2-chloro-4-fluorophenyl)ethyl]amino}-N-methylacetamide hydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2024, 1025, 2973-2987.

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