2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid CAS 1338977-53-9

2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid

纯度 97%+现货药物标准品
CAS 号1338977-53-9
分子式C10H13NO4
分子量211.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid CAS 1338977-53-9 结构式 Chemical Structure

产品介绍 Description

2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid（英文名 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid，CAS 1338977-53-9）属于药物标准品。分子式 C10H13NO4，分子量 211.21。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid的分子量为211.21 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid（2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid），CAS注册编号 1338977-53-9，化学分子式为 C10H13NO4，分子量 211.21 g/mol。 依据分子式为 C10H13NO4 的2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 211.2

应用场景：2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid（2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶

理化性质 Physical & Chemical Properties

中文名称2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid
分子式C10H13NO4
分子量211.21 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数1

相关专利 Related Patents

  1. 发明人唐晓军，李文辉，郭海燕. "一种2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 108185453 B, 授权公告日 2021-04-13.
  2. 发明人黄志刚，韩伟，李文辉. "Method for the Synthesis of 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid" [P]. 中国发明专利, 专利号 CN 109293329 B, 授权公告日 2024-02-11.
  3. Chen K W, Williams B T, Davis P L. "A Process for Preparing High-Purity 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid" [P]. US Patent, US 10892961 B2, 2015-04-13.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid in Pharmaceutical Formulations". J. Sep. Sci., 2023, 375, 6382-6397.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid as an Impurity". Chemosphere, 2022, 1445, (12), 3238-3260.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid Using HRMS and NMR". Sci. Total Environ., 2013, 2054, (4), 4570-4595.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 2-hydroxy-2-methyl-3-(4-methyl-2-oxo-1,2-dihydropyridin-1-yl)propanoic acid Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2021, 1679, (11), 256-278.

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