3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester CAS 1341035-98-0

3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester

纯度 97%+现货药物标准品
CAS 号1341035-98-0
分子式C17H31BrN4O3Si
分子量447.44 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester 3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester CAS 1341035-98-0 结构式 Chemical Structure

产品介绍 Description

CAS 1341035-98-0 对应的3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester（3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester）为 CATO 佳途药物标准品产品线成员。分子式 C17H31BrN4O3Si，分子量 447.44。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 CAS编号 1341035-98-0 对应的化合物3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-1,2,3Triazolo1,5-APyrazine-5-Carboxylic Acid Tert-Butyl Ester（英文标识 3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-1,2,3Triazolo1,5-APyrazine-5-Carboxylic Acid Tert-Butyl Ester），化学式 C17H31BrN4O3Si，相对分子质量 447.44。 受分子结构中甾体骨架，酰

应用场景：3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H- 1,2,3 Triazolo 1,5-A Pyrazine-5-Carboxylic Acid Tert-Butyl Ester（3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H- 1,2,3 Triazolo 1,5-A Pyrazine-5-Carboxylic Acid Tert-Butyl Ester）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以3-Bromo-6

理化性质 Physical & Chemical Properties

中文名称3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester
分子式C17H31BrN4O3Si
分子量447.44 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Br取代
含氮原子数4

相关专利 Related Patents

  1. Rossi M, Björnsson E, Kowalski A. "一种3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester的合成方法" [P]. European Patent, EP 3653649 A1, 2023-01-26.
  2. Roberts E F, Johnson M A, Lee S K. "Method for the Synthesis of 3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester" [P]. US Patent, US 10158477 B2, 2018-03-27.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester in Pharmaceutical Formulations". Sci. Total Environ., 2014, 2344, 25-48.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester as an Impurity". Rapid Commun. Mass Spectrom., 2021, 2403, 3951-3969.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 3-Bromo-6-(Tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid Tert-Butyl Ester Using HRMS and NMR". Anal. Chem., 2017, 2302, 5178-5197.

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