N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide CAS 1358044-81-1

N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide

纯度 97%+现货药物标准品
CAS 号1358044-81-1
分子式C17H14ClN3O2
分子量327.76 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide CAS 1358044-81-1 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide（N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide）为药物标准品，CAS 登记号 1358044-81-1，分子式 C17H14ClN3O2，分子量 327.76。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C17H14ClN3O2 的N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide（N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide），其CAS登记号是 1358044-81-1，分子量为 327.76 g/mol。 N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide（C17H14ClN3O2）含有甾体骨架，酰胺类，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中的氮原子赋予该化

应用场景：N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide（N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide，CAS 1358044-81-1）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide
分子式C17H14ClN3O2
分子量327.76 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人朱建伟，罗永刚，孙丽萍. "一种N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide的合成方法" [P]. 中国发明专利, 专利号 CN 113304200 B, 授权公告日 2020-08-11.
  2. 发明人何建平，黄志刚，杨光. "Method for the Synthesis of N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide" [P]. 中国发明专利, 专利号 CN 115087421 B, 授权公告日 2020-01-07.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide in Pharmaceutical Formulations". Environ. Sci. Technol., 2025, 1662, (6), 8525-8553.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide as an Impurity". Phytochemistry, 2020, 2108, (1), 5195-5208.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide Using HRMS and NMR". J. Sep. Sci., 2018, 1102, 11-37.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate N-(4-chloro-2-methylphenyl)-5-methyl-3-(pyridin-3-yl)-1,2-oxazole-4-carboxamide Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2019, 1688, (3), 6285-6311.

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