3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride CAS 1389310-02-4

3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride

纯度 97%+现货药物标准品
CAS 号1389310-02-4
分子式C11H15N3O2S HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride CAS 1389310-02-4 结构式 Chemical Structure

产品介绍 Description

3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride（英文名 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride，CAS 1389310-02-4）属于药物标准品。分子式 C11H15N3O2S HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

作为认证标准物质（CRM），3-(3R)-Pyrrolidin-3-yl-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C11H15N3O2S HCl 的3-(3R)-Pyrrolidin-3-yl-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride（3-(3R)-Pyrrolidin-3-yl-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride），其CAS登记号是 1389310-02-4，分子量为 289.78 g/mol。 受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含氯取代的影响，3

应用场景：3- (3R)-Pyrrolidin-3-yl -3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride（3- (3R)-Pyrrolidin-3-yl -3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride，CAS 1389310-02-4）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3- (3R)-Pyrrolidin-3-yl -3,4-dihydro-1H-2lambda(6),1,3-benzoth

理化性质 Physical & Chemical Properties

中文名称3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride
分子式C11H15N3O2S HCl
分子量289.78 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. 发明人郑宇鹏，钱学锋，高志强. "一种3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 112905142 A, 授权公告日 2021-08-28.
  2. 发明人马晓峰，罗永刚，唐晓军. "Method for the Synthesis of 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride" [P]. 中国发明专利, 专利号 CN 114825840 A, 授权公告日 2017-04-14.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride in Pharmaceutical Formulations". Chromatographia, 2016, 1175, 4688-4701.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride as an Impurity". Sci. Total Environ., 2025, 137, (4), 1695-1701.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride Using HRMS and NMR". Food Chem., 2018, 162, (12), 3801-3805.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride Profile in Drug Substances According to ICH Guidelines". Molecules, 2015, 303, 6577-6595.

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