Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate CAS 1391733-64-4

Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate

纯度 97%+现货药物标准品
CAS 号1391733-64-4
分子式C13H22INO3
分子量367.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate CAS 1391733-64-4 结构式 Chemical Structure

产品介绍 Description

Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate（英文名 Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate，CAS 1391733-64-4）属于药物标准品。分子式 C13H22INO3，分子量 367.22。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro3,2-cpyridine-5(6H)-carboxylate在内的目标物的控制。 化学式为 C13H22INO3 的Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro3,2-cpyridine-5(6H)-carboxylate（Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro3,2-cpyridine-5(6H)-carboxylate），其CAS登记号是 1391733-64-4，分子量为 367.22 g/mol。 受分子结构中酰胺类，羧酸类，含羟基，含醚键，含碘取代的影响，Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro3,2-cpyridine-5(6H)-carboxyla

应用场景：针对化学分析用途，Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro 3,2-c pyridine-5(6H)-carboxylate（Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro 3,2-c pyridine-5(6H)-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro 3,2-c pyridine-5(6H)-ca

理化性质 Physical & Chemical Properties

中文名称Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate
分子式C13H22INO3
分子量367.22 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1991年
卤素含量I取代
含氮原子数1

相关专利 Related Patents

  1. 发明人黄志刚，李文辉，陈志强. "一种Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 110932688 B, 授权公告日 2018-11-06.
  2. Kumar R, Stevens L M, Davis P L. "Method for the Synthesis of Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate" [P]. US Patent, US 11186031 B2, 2016-07-22.
  3. Mueller T, Lee S K, O'Brien P Q. "A Process for Preparing High-Purity Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate" [P]. US Patent, US 9793569 B2, 2022-01-27.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate in Pharmaceutical Formulations". Phytochemistry, 2019, 2408, (5), 8673-8700.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate as an Impurity". J. Chromatogr. A, 2016, 1133, 656-681.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate Using HRMS and NMR". Molecules, 2015, 293, 8106-8122.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate Racemic-(2S,3aR,7aS)-tert-butyl 2-(iodomethyl)hexahydrofuro[3,2-c]pyridine-5(6H)-carboxylate Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2019, 213, (7), 2109-2118.

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