2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈 CAS 1425381-60-7

2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile

纯度 97%+现货药物标准品
CAS 号1425381-60-7
分子式C24H28N8O2
分子量460.53 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈 2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile CAS 1425381-60-7 结构式 Chemical Structure

产品介绍 Description

2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈（2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile）是药物分析与质量控制领域常用的药物标准品，CAS 号 1425381-60-7。分子式 C24H28N8O2，分子量 460.53。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并4,5-d哒嗪-2-基)哌啶-4-基)乙腈的产生途径与其化学式中甾体骨架，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C24H28N8O2 的2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并4,5-d哒嗪-2-基)哌啶-4-基)乙腈（2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido4,5-dpyridazin-2-yl)piperidin-4-yl)acetonitrile），其CAS登记号是 1425381-60-7，分子量为 460.53 g/mol。 依据分子式为 C24H28N8O2 的2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并4,5-d哒嗪-2-基)哌啶-4-基)乙腈结构特征，其分子内含甾体骨架，酰胺类，含羟基，含醚键

应用场景：针对化学分析用途，2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并 4,5-d 哒嗪-2-基)哌啶-4-基)乙腈（2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido 4,5-d pyridazin-2-yl)piperidin-4-yl)acetonitrile）是具有明确定量溯源的认证级对照品。 推荐以2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并 4,5-d 哒嗪-2-基)哌啶-4-基)乙腈配制标准系列

理化性质 Physical & Chemical Properties

中文名称2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈
分子式C24H28N8O2
分子量460.53 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）15.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数8

相关专利 Related Patents

  1. 发明人冯建国，唐晓军，王建平. "一种2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈的合成方法" [P]. 中国发明专利, 专利号 CN 108195243 B, 授权公告日 2016-03-02.
  2. 发明人刘建华，孙丽萍，赵玉洁. "Method for the Synthesis of 2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile" [P]. 中国发明专利, 专利号 CN 114721547 A, 授权公告日 2017-04-14.
  3. Yamamoto T, Chen K W, Lee S K. "A Process for Preparing High-Purity 2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile" [P]. US Patent, US 9161989 B2, 2015-06-25.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈 in Pharmaceutical Formulations". Food Chem., 2020, 1187, (5), 7035-7045.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈 as an Impurity". Sci. Total Environ., 2022, 2287, (2), 3426-3453.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile Using HRMS and NMR". J. Chromatogr. A, 2016, 2064, (11), 601-606.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2010, 809, (5), 3868-3893.

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