2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-基)氨基)咪唑并[1,2-b]哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并[1,2-a]吲哚-1(2H)-酮 CAS 1433820-83-7

2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)imidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one

纯度 97%+现货药物标准品
CAS 号1433820-83-7
分子式C30H32N10O2
分子量564.64 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-基)氨基)咪唑并[1,2-b]哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并[1,2-a]吲哚-1(2H)-酮 2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)imidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one CAS 1433820-83-7 结构式 Chemical Structure

产品介绍 Description

CAS 1433820-83-7 对应的2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-基)氨基)咪唑并[1,2-b]哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并[1,2-a]吲哚-1(2H)-酮（2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)imidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one）为 CATO 佳途药物标准品产品线成员。分子式 C30H32N10O2，分子量 564.64。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并1,5-a吡嗪-2-基)氨基)咪唑并1,2-b哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并1,2-a吲哚-1(2H)-酮在内的目标物的控制。 CAS编号 1433820-83-7 对应的化合物2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并1,5-a吡嗪-2-基)氨基)咪唑并1,2-b哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并1,2-a吲哚-1(2H)-酮（英文标识 2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo1,5-apyrazin-2-yl)amino)imidazo1,2-bpyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino1,2-aindol-1(2H)-one），化学式 C30H32N10O2，相对

应用场景：2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并 1,5-a 吡嗪-2-基)氨基)咪唑并 1,2-b 哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并 1,2-a 吲哚-1(2H)-酮（2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo 1,5-a pyrazin-2-yl)amino)imidazo 1,2-b pyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino 1,2-a indol-1(2H)-one，CAS

理化性质 Physical & Chemical Properties

中文名称2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-基)氨基)咪唑并[1,2-b]哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并[1,2-a]吲哚-1(2H)-酮
分子式C30H32N10O2
分子量564.64 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）20.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数10

相关专利 Related Patents

  1. 发明人郭海燕，韩伟，高志强. "一种2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-基)氨基)咪唑并[1,2-b]哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并[1,2-a]吲哚-1(2H)-酮的合成方法" [P]. 中国发明专利, 专利号 CN 108298558 B, 授权公告日 2016-10-19.
  2. 发明人沈红梅，马晓峰，韩伟. "Method for the Synthesis of 2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)imidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one" [P]. 中国发明专利, 专利号 CN 108317605 A, 授权公告日 2021-12-14.
  3. Rossi M, Sørensen M, Mueller T C. "A Process for Preparing High-Purity 2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)imidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one" [P]. European Patent, EP 3157010 A1, 2016-05-24.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-基)氨基)咪唑并[1,2-b]哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并[1,2-a]吲哚-1(2H)-酮 in Pharmaceutical Formulations". Biomed. Chromatogr., 2025, 1329, 3159-3181.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(3-(羟甲基)-4-(8-((5-甲基-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-基)氨基)咪唑并[1,2-b]哒嗪-6-基)吡啶-2-基)-3,4,6,7,8,9-六氢吡嗪并[1,2-a]吲哚-1(2H)-酮 as an Impurity". J. Sep. Sci., 2018, 2414, (12), 3826-3833.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 2-(3-(Hydroxymethyl)-4-(8-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)imidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one Using HRMS and NMR". J. Pharm. Biomed. Anal., 2020, 1210, 2565-2594.

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