7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE CAS 1447608-16-3

7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE

纯度 97%+现货药物标准品
CAS 号1447608-16-3
分子式C17H13BrN2O3
分子量373.20 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE CAS 1447608-16-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE（7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE，CAS 1447608-16-3），分子式 C17H13BrN2O3，分子量 373.20。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

CAS编号 1447608-16-3 对应的化合物7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE（英文标识 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE），化学式 C17H13BrN2O3，相对分子质量 373.20。 从化学结构特征来看，7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE的分子骨架中包含甾体骨架，酰胺类，含羟基，含醚键，含溴取代。该化合物的不饱和度为12.0，表明结构中存在约12个环或双键等价单元。分子量为373.20 g/mol，属于较高分子量化合物。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GL

应用场景：7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE（7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE，CAS 1447608-16-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE
分子式C17H13BrN2O3
分子量373.20 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
卤素含量Br取代
含氮原子数2

相关专利 Related Patents

  1. 发明人罗永刚，徐明华，郑宇鹏. "一种7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE的合成方法" [P]. 中国发明专利, 专利号 CN 116664909 A, 授权公告日 2017-07-19.
  2. 发明人周伟，林芳，马晓峰. "Method for the Synthesis of 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE" [P]. 中国发明专利, 专利号 CN 110556898 A, 授权公告日 2017-09-08.
  3. 发明人朱建伟，赵玉洁，黄志刚. "A Process for Preparing High-Purity 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE" [P]. 中国发明专利, 专利号 CN 111794105 A, 授权公告日 2022-11-11.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE in Pharmaceutical Formulations". J. Nat. Prod., 2022, 2184, 6182-6188.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE as an Impurity". J. Chromatogr. A, 2018, 1066, 9908-9932.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE Using HRMS and NMR". J. Agric. Food Chem., 2011, 1353, (6), 7804-7816.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 7-BROMO-1-(4-HYDROXY-2-METHYLPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2010, 1444, (6), 2407-2416.

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